退癀消肿汤联合洛索洛芬钠片治疗急性痛风性关节炎的临床研究  

Clinical study on Tuihuang Xiaozhong Tang( 退癀消肿汤) combined with loxoprofen sodium tablets for treatment of acute gouty arthritis

作　　者：陈鹏[1] 郭文韬[1] 龙美兵 李楠[1] 

机构地区：[1]福建中医药大学,福建福州350122

出　　处：《中医正骨》2016年第8期19-23,共5页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：福建中医药大学校管科研课题项目(X2015003-平台)

摘　　要：目的:观察退癀消肿汤联合洛索洛芬钠片治疗急性痛风性关节炎的临床疗效和安全性。方法:将60例急性痛风性关节炎患者随机分为2组,每组30例,分别采用口服退癀消肿汤联合洛索洛芬钠片、口服秋水仙碱片联合洛索洛芬钠片治疗。退癀消肿汤每袋200 m L,每日早、晚餐后30 min服用1袋;洛索洛芬钠片每次60 mg,每日2次,饭后服用;秋水仙碱片每日服用3次,开始负荷剂量为1.0 mg,1 h后服用0.5 mg,12 h后服用0.5 mg;上述药物连续服用2周。分别于治疗前和治疗结束后2周比较2组患者白细胞介素(interleukin^(-1),IL^(-1))、IL-6及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)的血清含量,并于治疗结束后2周比较2组患者的临床疗效及并发症发生情况。结果:1炎性因子血清含量。治疗前2组患者IL^(-1)、IL-6、TNF-α血清含量比较,组间差异均无统计学意义[(50.33±6.26)μg·g^(-1),(51.12±8.32)μg·g^(-1),t=-0.614,P=0.094;(43.27±7.14)μg·g^(-1),(41.35±8.27)μg·g^(-1),t=1.775,P=0.081;(55.23±9.71)pg·m L^(-1),(56.31±6.76)pg·m L^(-1),t=-0.587,P=0.075]。治疗结束后2周,退癀消肿汤联合洛索洛芬钠片组IL^(-1)血清含量与秋水仙碱片联合洛索洛芬钠片组比较,差异无统计意义[(34.28±4.57)μg·g^(-1),(35.16±6.73)μg·g^(-1),t=-0.701,P=0.176];退癀消肿汤联合洛索洛芬钠片组IL-6、TNF-α血清含量均低于秋水仙碱片联合洛索洛芬钠片组[(24.25±3.36)μg·g^(-1),(30.21±3.13)μg·g^(-1),t=^(-1)1.619,P=0.000;(41.16±5.39)pg·m L^(-1),(47.57±2.31)pg·m L^(-1),t=-8.741,P=0.000];2组患者IL^(-1)、IL-6、TNF-α血清含量均低于治疗前(t=56.716,P=0.000;t=28.734,P=0.000;t=25.524,P=0.000;t=12.062,P=0.000;t=23.538,P=0.000;t=18.330,P=0.000)。2临床疗效。治疗结束后2周,参照《中医病证诊断疗效标准》中痛风的疗效评定标准,退癀消肿汤联合洛索洛芬钠片组痊愈18例、显效6例、有效4例、无效2例,秋水仙碱片联合洛索洛芬钠片组痊愈Objective：To observe the clinical curative effects and safety of Tuihuang Xiaozhong Tang（退癀消肿汤,THXZT）combined with loxoprofen sodium tablets for treatment of acute gouty arthritis. Methods：Sixty patients with acute gouty arthritis were enrolled in the study and were randomly divided into 2 groups,30 cases in each group. The patients were treated with oral application of THXZT and loxo-profen sodium tablets（group A）and oral application of colchicine tablets and loxoprofen sodium tablets（group B）respectively. The THXZT were taken at a dose of 200 mL at 30 minutes after breakfast and dinner respectively. The loxoprofen sodium tablets were taken at a dose of 60 mg after the meal,twice a day. The colchicine tablets were taken 3 times a day at a dose of 1. 0 mg（initial loading dose）,0. 5 mg（1 hour later）and 0. 5 mg（12 hours later）respectively. All of the drugs were taken for consecutive 2 weeks. The serum contents of interleukin - 1 （IL - 1）,IL - 6 and tumor necrosis factor - α（TNF - α）were detected and compared between the 2 groups before treatment and at 2 weeks after the end of the treatment respectively,and the clinical effects and complication rates were compared between the 2 groups at 2 weeks af-ter the end of the treatment. Results：There was no statistical difference in the serum contents of IL - 1,IL - 6 and TNF - α between the 2 groups before treatment（50. 33 ＋/- 6. 26 vs 51. 12 ＋/- 8. 32 μg/ g,t = - 0. 614,P = 0. 094;43. 27 ＋/- 7. 14 vs 41. 35 ＋/- 8. 27 μg/ g,t =1. 775,P = 0. 081;55. 23 ＋/- 9. 71 vs 56. 31 ＋/- 6. 76 pg/ mL,t = - 0. 587,P = 0. 075）. At 2 weeks after the end of the treatment,there was no statistical difference in the serum contents of IL - 1 between group A and group B（34. 28 ＋/- 4. 57 vs 35. 16 ＋/- 6. 73 μg/ g, t = - 0. 701,P = 0. 176）and the serum contents of IL - 6 and TNF - α were lower in group A compared to group B（24. 25 ＋/- 3. 36 vs 30. 21 ＋/- 3. 13 μg/ g,t = - 11. 619,P = 0. 000;41. 16 ＋/- 5. 39 vs

关 键 词：关节炎 痛风性退癀消肿汤 秋水仙碱 洛索洛芬钠 临床试验 

分 类 号：R589.7[医药卫生—内分泌]