辛伐他汀联合苯磺酸氨氯地平对老年高血压合并高血脂症患者血液流变学、血小板活化的影响  

Effects of simvastatin combined with amlodipine besylate on blood rheology and platelet activation in elderly patients with hypertension complicated with hyperlipemia

作　　者：蒋明争 李琼[2] 刘会 

机构地区：[1]重庆建设医院老年科,重庆400050 [2]大坪医院神经内科,重庆400042 [3]重庆建设医院急诊科,重庆400050

出　　处：《海南医学院学报》2016年第17期1958-1961,共4页Journal of Hainan Medical University

基　　金：重庆市科技攻关计划项目(BARQ2013AC1026)~~

摘　　要：目的:探讨辛伐他汀联合苯磺酸氨氯地平对老年高血压合并高血脂症患者血液流变学、血小板活化的影响。方法:将200例于我院初诊为高血压和(或)高血脂老年患者,根据血压、血脂分为高血压组64例,高血脂组71例,高血压合并高血脂症患者65例作为合并组,另选同期健康体检者100例作为对照组。高血压组采用苯磺酸氨氯地平单药治疗,高血脂组采用辛伐他汀单药治疗,合并组采用辛伐他汀和苯磺酸氨氯地平联合治疗,3组均治疗12周。比较治疗前、后4组血液流变学、血小板活化情况。结果:治疗后,高血压组和合并组血压及血脂明显较治疗前降低,且合并组降低更显著,差异均具有统计学意义(P<0.05);治疗前,3组血液流变学指标全血黏度(高、低切)、血浆黏度和血小板活化指标CD62p、CD63水平均较对照组明显升高,且合并组较高血压组和高血脂组升高更显著,差异均具有统计学意义(P<0.05);治疗后,高血脂组和合并组全血黏度(高、低切)、血浆黏度水平和CD62p、CD63水平均较治疗前明显降低,且合并组降低幅度更显著,差异均具有统计学意义(P<0.05)。结论:辛伐他汀联合苯磺酸氨氯地平治疗后可明显改善老年高血压合并高血脂症患者血压、血脂、血液流变及血小板异常。[ABSTRACT]Objective：To investigate the effects of simvastatin combined with amlodipine besylate on blood rheology and platelet activationin in elderly patients with hypertension complicated with hyperlipemia.Methods：A total of 200 elderly pa-tients with hypertension complicated with hyperlipemia were divided into hypertension group （n =64）,hyperlipemia group （n=71）and combined （hypertension complicated with hyperlipemia group （n =65）.And alternate period health check-up 100 ca-ses as control group.The hypertension group amlodipine besylate monotherapy,hyperlipidemia group with simvastatin mono-therapy,combined group received simvastatin combined with amlodipine besylate treatment,patients of three groups were treated for 12 weeks.Comparison of 4 groups the blood rheology,platelet activation before and after treatment.Results：After treatment,blood pressure was obviously lower than that before treatment in hypertension and combined group （P 〈0.05）,andnbsp;the combined group reduced more significantly （P 〈0.05）,blood fat was significantly lower than that before treatment in hy-perlipemia and combined group （P 〈 0.05 ）,and combined group reduced more significantly （P 〈 0.05 ）;Before treatment, three groups of indexes of blood rheology （high shear whole blood viscosity,low shear whole blood viscosity,plasma viscosity, fibrinogen and platelet activation index（CD62p and CD63）were significantly higher than those in control group （P 〈0.05）,and the combined group increased more significantly than hypertension and hyperlipidemia group （P 〈 0.05 ）;After treatment, blood rheology （high shear whole blood viscosity,low shear whole blood viscosity,plasma viscosity,fibrinogen and platelet ac-tivation index （CD62p and CD63）of hyperlipidemia group and combined group were significantly lower than before treatment （P 〈0.05）,and the combined group were greater reduction in amplitude （P 〈0.05）.Conclusion：Simvastatin combined amlo-dipine besylate therapy c

关 键 词：高血压合并高血脂症 辛伐他汀 苯磺酸氨氯地平 血液流变学 血小板活化 

分 类 号：R544.1[医药卫生—心血管疾病]