微生态制剂联合锌制剂治疗对小儿迁延性腹泻血清相关指标的影响  

Effect of probiotics combined with zinc preparation treatment on serum related indicators in children with protracted diarrhea

作　　者：李晓冰[1] 何德根[1] 彭通 王信芳[1] 陈敬国[2] 

机构地区：[1]广州中医药大学附属中山中医院儿科,广东中山528400 [2]广东省中山市人民医院儿科,广东中山528403

出　　处：《海南医学院学报》2016年第17期1979-1982,共4页Journal of Hainan Medical University

基　　金：中山市科技局项目(20113A078)~~

摘　　要：目的:分析微生态制剂联合锌制剂治疗对小儿迁延性腹泻血清相关指标的影响。方法:70例迁延性腹泻患儿纳入本次研究,随机分为观察组及对照组各35例。对照组接受单独微生态制剂治疗,观察组接受微生态制剂联合锌制剂治疗,对比两组血清相关指标值差异。结果:观察组治疗后血清NO、MDA、GAS、sIL-2R值低于对照组,SOD、RGE_2、IgA、IgM、IgG、锌值高于对照组,差异具有统计学意义(P<0.05);血清中IL-6、IL-8、hs-CRP、PCT、HMGB1等炎症指标值低于对照组,差异具有统计学意义(P<0.05)。结论:微生态制剂联合锌制剂治疗可以优化迁延性腹泻患儿整体病情、恢复内环境稳态,具有积极的临床意义。Objective：To analyze the effect of probiotics combined with zinc preparation treatment on serum related in-dicators in children with protracted diarrhea.Methods：A total of 70 children with protracted diarrhea were included in the stud-y and randomly divided into observation group and control group （n =35）.Control group accepted probiotics treatment alone, observation group received probiotics combined with zinc preparation treatment,and differences in serum related indicator val-ues were compared between two groups.Results：Serum NO,MDA,GAS and sIL-2R values of observation group after treat-ment were lower than those of control group,and SOD,RGE2 ,IgA,IgM,IgG and zinc values were higher than those of con-trol group （P 〈0.05）;serum inflammatory markers IL-6,IL-8,hs-CRP,PCT and HMGB1 values were lower than those of control group （P 〈0.05）.Conclusion：Probiotics combined with zinc preparation treatment can optimize the overall conditions and restore homeostasis in children with protracted diarrhea,and has positive clinical significance.

关 键 词：小儿迁延性腹泻 微生态制剂 锌制剂 

分 类 号：R725.7[医药卫生—儿科]