支原体肺炎患儿接受顺尔宁联合丙卡特罗治疗后的气道重塑、炎症反应的评估  

Assessment of airway remodeling and inflammatory response in children with mycoplasma pneumonia after montelukast combined with procaterol treatment

作　　者：张建梅 张粉霞[2] 加妍 王敏 白珏 

机构地区：[1]陕西省延安市宝塔区人民医院儿科 [2]陕西省延安市人民医院儿科,陕西延安716000

出　　处：《海南医学院学报》2016年第17期1983-1985,1988,共4页Journal of Hainan Medical University

基　　金：陕西省教育厅(06JK037)~~

摘　　要：目的:研究顺尔宁联合丙卡特罗治疗对支原体肺炎患儿气道重塑、炎症反应的影响。方法:选择60例我院收治的支原体肺炎合并哮喘急性发作患儿,随机分为两组,观察组接受常规抗感染、止咳化痰联合顺尔宁、丙卡特罗解痉平喘治疗,对照组接受常规抗感染、止咳化痰联合丙卡特罗解痉平喘治疗,评估两组患儿的气道重塑程度以及炎症反应程度。结果:两组治疗后1周时的血清MCP-4、MDC、CysLTs含量均显著低于治疗前且观察组治疗后的血清MCP-4、MDC、CysLTs含量低于对照组;治疗后1周时,观察组LD以及诱导痰中Treg的比例显著高于对照组,WT、WA%、PEF25、PEF50、PEF75以及诱导痰中FN1、Col-1的含量、Th17的比例显著低于对照组,FVC、PEF、FEV1与对照组无差异。结论:顺尔宁联合丙卡特罗治疗对支原体肺炎合并哮喘急性发作患儿的气道重塑、炎症反应均具有显著的改善作用。[ABSTRACT]Objective：To study the effects of montelukast combined with procaterol treatment on airway remodeling and inflammatory response in children with mycoplasma pneumonia.Methods：60 cases of Mycoplasma pneumonia children with a-cute asthma attack treated in our hospital were selected and randomly divided into two groups,observation group received con-ventional anti-infection,cough-relieving and sputum-reducing combined with montelukast and procaterol spasmolysis and asth-ma-relieving treatment,control group received conventional anti-infection,cough-relieving and sputum-reducing combined with procaterol spasmolysis and asthma-relieving treatment,and then the degree of airway remodeling and inflammatory response was compared between two groups.Results：Serum MCP-4,MDC and CysLTs levels of both groups 1 week after treatment were significantly lower than those before treatment and serum MCP-4,MDC and CysLTs levels of observation group after treatment were lower than those of control group;1 week after treatment,LD and the proportion of Treg in induced sputum of observation group were significantly higher than those of control group,WT,WA%,PEF25,PEF50 and PEF75 as well asnbsp;FN1 and Col-1 levels and the proportion of Th1 7 in induced sputum were significantly lower than those of control group,and FVC,PEF and FEV1 were not different from those of control group.Conclusion：Montelukast combined with procaterol treat-ment can significantly improve the airway remodeling and inflammatory response in mycoplasma pneumonia children with acute asthma attack.

关 键 词：支原体肺炎 支气管哮喘 顺尔宁 气道重塑 炎症反应 

分 类 号：R563.1[医药卫生—呼吸系统]