肺炎支原体肺炎患儿血清IL-6及sIL-6R活性的研究  

The Study of Serum IL-6 and sIL-6 receptor of children with mycoplasmal pneumoniae pneumonia

作　　者：金婧[1] 李晓菊[2] 蔡栩栩[1] 赵淑琴[1] 高云霞[1] 张正侯[1] 

机构地区：[1]中国医科大学第二临床学院儿科,辽宁沈阳110004 [2]沈阳市儿童医院,沈阳110032

出　　处：《小儿急救医学》2002年第3期143-144,共2页Pediatric Emergency Medicine

摘　　要：目的　研究 MPP患儿血清 IL -6及 s IL -6 R含量变化 ,探讨其在 MPP发病机制中的作用。 方法　用 EL ISA法对41例 MPP患儿急性期及恢复期血清 IL -6及 s IL -6 R进行测定。结果　 1MPP患儿血清 IL -6及 s IL -6 R含量在急性期及恢复期均明显高于对照组 ( P<0 .0 1) ;血清 IL-6含量恢复期较急性期明显下降 ( P<0 .0 1) ,而 s IL-6 R在恢复期则持续保持高水平 ;2血清 IL-6含量在病情重的 MPP患儿明显高于病情轻组 ( P<0 .0 1) ,血清 s IL-6 R间的差异无统计学意义 ( P>0 .0 5 )。 结论 　血清IL-6及 s IL -6 R参与 MPP患儿的免疫状态改变 ,在Objective To study the changes of serum IL-6 and sIL-6 R children with MPP.Methods Enzyme linked immunoassay was used to measure serum IL-6 and sIL-6 R of children with MPP in different stages.Results The result showed that serum IL-6 and sIL-6 R of MPP were significantly higher than those of normal control in both acute and convalescent stages (P<0^01) and serum IL-6 in convalescent stage was significantly decreased as compared with acute stage (P<0^01),while serum sIL-6 R maintained high level in convalescent stage.Serum IL-6 were significantly higher in severe patients than mild patients.Conclusion Serum IL-6 and sIL-6 R may cause the changes of immune state of children with MPP. Serum IL-6 and sIL-6 R were related to the pathogenesis of MPP.

关 键 词：肺炎支原体肺炎 白细胞介素-6 可溶性白细胞介素-6受体 儿童 

分 类 号：R725.6[医药卫生—儿科]