OSAS合并2型糖尿病患者IL-6及IL-8水平的研究  

Obstructie sleep apnea(osa) with type 2 diabetes IL- 6 and IL 8 levels of study

作　　者：李业梅[1] 俞小卫[1] 左一俊[1] 

机构地区：[1]南京医科大学附属常州第二人民医院呼吸科,江苏常州213003

出　　处：《临床医药文献电子杂志》2016年第25期4927-4927,4929,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的探索研究阻塞性睡眠呼吸暂停（OSAS）合并2型糖尿病（T2DM）患者的IL-6及IL-8相关炎症因子水平。方法选取2015年9月-2016年2月我院收治的OSAS合并T2DM患者150例,单纯患有OSAS患者152例及正常成人150名作为研究对象,分别以ELISA法监测其血清中IL-6及IL-8浓度。结果在OSAS＋T2DM组,OSAS组,IL-6及IL-8水平均较对照组明显增高,差异有统计学意义（P〈0.05）,OSAS＋T2DM组的IL-6及IL-8水平更高,差异有统计学意义（P〈0.05）。结论 OSAS合并2型糖尿病能够引起相关炎症因子水平增高,深入探讨考察其水平的参考值及不良影响需要引起重视。Objective To explore the research on Obstructive Sleep Apnea（Obstructive Sleep Apnea Syndrome,OSAS） combined with type 2 diabetes（type 2 diabetes mellitus, T2DM） in patients with IL- 6 and IL- 8 related inflammatory factor levels. Methods Selected in our hospital between September 2015- February 2016 treated 150 cases of OSAS combined T2 DM patients, 152 cases of simple patients with OSAS patients and 150 normal adults as the research object, with ELISA method for monitoring the concentration of serum IL- 6 and IL- 8. Results In the OSAS ＋ T2 DM group, OSAS group, IL- 6 and IL- 8 levels were significantly higher than the control group（P〈0.05）, and also is significant difference between the two groups, before the OSAS ＋ T2 DM group of IL- 6 and IL- 8 levels higher, statistically significant difference（P〈0.05）. Conclusion Obstructive sleep apnea with type 2 diabetes can cause related infection factor leels, probe to investigate the levels of reference and adverse effects need to cause clinical value.

关 键 词：OSAS 2型糖尿病 IL-6 IL-8 

分 类 号：R766[医药卫生—耳鼻咽喉科]