湖南长沙市结核分枝杆菌耐药情况分析  

Drug resistance analysis on Mycobacterium tuberculosis in patients with pulmonary tuberculosis in Changsha area

作　　者：潘建华[1] 罗丹[1] 石国民[1] 彭雪峰[1] 向延根[1] 

机构地区：[1]长沙市中心医院检验科,湖南长沙410004

出　　处：《临床肺科杂志》2016年第10期1751-1753,1756,共4页Journal of Clinical Pulmonary Medicine

基　　金：国家"十二五"重大专项(No.2013ZX10005004)

摘　　要：目的了解长沙地区结核分枝杆菌耐药情况。方法分析本院2012年1月-2015年10月分离的6198株结核分枝杆菌对7种抗结核药物的耐药情况。结果 6198株结核分枝杆菌复合群菌株耐药率顺位前5位依次为INH（14.18%）、RFP（13.57%）、SM（12.31%）、EMB（3.87）、OFLX（2.60）;总耐药率为20.56%,耐多药占9.31%,多耐药占4.52%,广泛耐药占0.45%;除2012年20岁以下年龄组女性耐药结核菌的检出率略高于男性外,其余年份各年龄组男性均高于女性;复治患者的耐药率（24.76%）高于初治患者（19.49%）,两者差异有统计学意义（χ^2=176.21,P〈0.001）;结论本院结核分枝杆菌耐药率总体低于全国第五次结核病流行病学调查结果,但耐多药率高于全国水平,耐药状况仍然严峻。Objective To investigate the current situation of Mycobacterium tuberculosis drug resistance in Changsha area. Methods A total of 6198 Mycobacterium tuberculosis strains were identified in Changsha Central Hospital from 2011 to 2015 and the sensitivity of Mycobacterium tuberculosis strains to 7 kinds of anti-tuberculosis drugs was performed. Results The top 5 of the drug resistance rates of 6198 strains of Mycobacterium tuberculosis complex group were INH（ 14. 18%）,RFP（ 13. 57%）,SM（ 12. 31%）,EMB（ 3. 87） and OFLX（ 2. 60）. The overall rate of resistance to anti-TB drugs was 20. 56%. MDR rate was 9. 31%. PDR rate was 4. 52% and XDR rate was 0. 45%. The detection rate of drug resistant tuberculosis of male was higher than female in all age groups except the female under 20 years old in 2012. The resistance in retreated patients was higher than in initial patients. Conclusion The prevalence of drug resistance of Mycobacterium tuberculosis in our hospital is lower than that of the fifth national tuberculosis epidemiological survey,but MDR rate is higher than the national level. Therefore,its drug resistance situation is still grim.

关 键 词：肺结核 结核分枝杆菌 抗结核药 耐药性 

分 类 号：R446.5[医药卫生—诊断学]