前S1抗原在乙型肝炎检测中的临床意义  

The Clinical Significance of Pre-S1 Antigen in Detection of Hepatitis B

作　　者：战伟[1] 

机构地区：[1]大连大学门诊部,辽宁大连116622

出　　处：《大连大学学报》2016年第3期84-86,共3页Journal of Dalian University

摘　　要：对236例乙肝表面抗原(HBs Ag)阳性患者血清标本的前S1抗原(Pre S1-Ag)及肝功能(HBV-DNA、ALT、AST和γ-GT)同时检测。前S1抗原阳性与HBV-DNA阳性高度一致(Kappa=0.65,P<0.05)。前S1抗原阴性组和阳性组ALT、AST和γ-GT进行比较,有显著性差别(P<0.05)。因与乙型肝炎的检测结果(ALT、AST及γ-GT)密切相关,前S1抗原在乙肝的诊断及预后方面有重要的临床意义。236 serum samples of patients with positive hepatitis B surface antigen（HBs Ag） have been simultaneously detected on their Pre-S1 Antigen（Pre S1-Ag） and liver functions（HBV-DNA,AST,ALT and γ-GT）. It has been found that the positive S1-Ag was in high accordance with the positive HBV-DNA（Kappa=0.65,P〈0.05）. The negative Pre S1-Ag group is quite different from the ALT, AST and γ-GT of the positive group（P〈0.05）. Because Pre S1-Ag is closely related with the ALT, AST and γ-GT, Pre S1-Ag has important clinical significance in the diagnosis and prognosis of hepatitis B.

关 键 词：乙型肝炎 前S1抗原 HBV–DNA 

分 类 号：R512.62[医药卫生—内科学]