合并隐源性肿瘤的肺栓塞患者危险因素分析  

Risk factors for occult cancer in patients with pulmonary embolism

作　　者：许明玲[1] 程兆忠[2] 王丽君[2] 邵艳梅[2] 王镜銮[2] 

机构地区：[1]青岛大学医学院,青岛266000 [2]青岛大学附属医院崂山院区呼吸科,青岛266000

出　　处：《中华实用诊断与治疗杂志》2016年第9期887-888,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家“十二五”科技支撑计划项目(2011BA11B17)

摘　　要：目的探讨肺栓塞（pulmonaryembolism，PE）患者合并隐源性肿瘤危险因素。方法290例PE患者，根据住院或随访2a期间是否合并恶性肿瘤分为肿瘤组20例，非肿瘤组270例。采用单因素及多因素logistic回归分析PE合并隐源性肿瘤的危险因素。结果单因素分析结果显示，年龄、特发性PE例数、D-二聚体水平、D-二聚体持续高水平例数、血红蛋白、红细胞计数、纤维蛋白原水平以及癌胚抗原（carcinoembryonicantigen，CEA）、糖类抗原125（carbohydrateantigen 125，CA025）与急性PE合并隐源性肿瘤有关（P〈0．05）；多因素logistic回归分析显示，年龄（OR=1．097，95％CI：1．002-1.201）、血红蛋白（OR=0．915，95％CI：0．840～0．996）、特发性PE（OR=22553．165，95％CI：12．764～32175．273）、CEA（OR=2．460，95％CI：1．350～4．481）、CA125（OR=1．035，95％CI：1．005～1．066）是PE合并隐源性肿瘤的独立危险因素。结论特发性PE、年龄、血红蛋白水平降低以及肿瘤标志物（CEA／cA125）水平增高可能是PE合并隐源性肿瘤的独立危险因素。Objective To investigate the risk factors for occult cancer in patients with pulmonary embolism （PE）. Methods The clinical data of 290 patients with PE were retrospectively analyzed. According to whether complicated with malignant tumors in hospital or during 2-year follow-up, 290 patients were divided into cancer group （n=20） and noncancer group （n= 270）. Univariate analysis and multivariable logistic regression analysis were used to analyze the risk factors for occult cancer in patients with PE. Results Univariate analysis showed that age, idiopathic PE, D-dimer, the constant elevated D-dimer level, hemoglobin, red blood cell, fibrinogen, carcinoembryonic antigen and carbohydrate antigen 125 were correlated with occult cancer in patients with acute PE （P〈0.05）. Multivariable logistic regression analysis showed that age （OR=1. 097, 95%CI：1. 002 to 1. 201）, hemoglobin （OR=0. 915, 95%CI：0. 840 to 0. 996）, idiopathic PE （OR=22 553. 165, 95%CI：12. 764 to 32175. 273）, carcinoembryonic antigen （OR=2. 460, 95%CI：1. 350 to 4. 481） and carbohydrate antigen 125 （OR= 1. 035,95% CI： 1. 005 to 1. 066） were the independent risk factors for occult cancer in patients with acute PE. Conclusion Idiopathic PE, age, decreased hemoglobin and increased tumor markers levels （carcinoembryonic antigen, carbohydrate antigen 125） might be the independent risk factors for occult cancer in patients with PE.

关 键 词：肺栓塞 隐源性肿瘤 危险因素 

分 类 号：R563.5[医药卫生—呼吸系统] R730.4[医药卫生—内科学]