Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue  

作　　者：LIU Nan XUE Ling GUAN Yi LI Qing Zhao CAO Fu Yuan PANG Shu Lan GUAN Wei Jun 

机构地区：[1]School of Public Health,North China University of Science and Technology,Hebei province coal mine health and safety laboratory

出　　处：《Biomedical and Environmental Sciences》2016年第8期584-588,共5页生物医学与环境科学（英文版）

基　　金：supported by the Applied Basic Research Program at Hebei Province in China(Grant No.11966120D)

摘　　要：Silicosis is one of the most serious occupational diseases in China and dates back to centuries ago. In this study, we successfully established a rat model of silicosis by intratracheal silica injection for 28 days and determined hydroxyproline levels to evaluate collagen metabolism in lung homogenates. Oxidative stress status was evaluated by detecting catalase and glutathione peroxidase activities.Silicosis is one of the most serious occupational diseases in China and dates back to centuries ago. In this study, we successfully established a rat model of silicosis by intratracheal silica injection for 28 days and determined hydroxyproline levels to evaluate collagen metabolism in lung homogenates. Oxidative stress status was evaluated by detecting catalase and glutathione peroxidase activities.

关 键 词：Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue SP Figure 

分 类 号：R135.2[医药卫生—劳动卫生]