子宫肌瘤与乳腺增生关联性的队列研究  

Relationship between uterine fibroid and hyperplasia of mammary glands: a cohort study

作　　者：李向一[1] 孙秀彬[1] 鹿玉莲[2] 申振伟 陈亚飞[1] 唐芳[3] 薛付忠[1] 

机构地区：[1]山东大学公共卫生学院生物统计学系,山东济南250012 [2]山东大学附属济南市中心医院,山东济南250013 [3]山东大学附属千佛山医院健康管理中心,山东济南250014

出　　处：《山东大学学报（医学版）》2016年第9期53-58,共6页Journal of Shandong University:Health Sciences

基　　金：山东省科技发展计划(2014GSF118119);山东省自然科学基金(ZR2015HL102)

摘　　要：目的基于队列设计探讨子宫肌瘤与乳腺增生的关联性。方法基于常规体检的大样本人群、纵向队列研究,终点事件为乳腺增生,采用Cox比例风险回归模型和Logistic回归模型探讨子宫肌瘤与乳腺增生的关联性。结果乳腺增生的发病密度为205.23/千人·年。未调整Cox模型显示子宫肌瘤对乳腺增生的相对危险度RR值为1.26（95%CI：1.12～1.43,P〈0.001）;调整年龄后,RR值变为1.37（95%CI：1.21～1.55,P〈0.001）;在上述模型基础上,将是否超重、饮酒、吸烟、睡眠质量等因素纳入多因素Cox模型后,RR值为1.36（95%CI：1.19～1.55,P〈0.001）。Logistic回归模型显示,子宫肌瘤对乳腺增生的HR值为1.94（95%CI：1.32～2.85,P〈0.001）。结论逐层加入危险因素进行调整后,子宫肌瘤与乳腺增生相关,说明子宫肌瘤患者未来发生乳腺增生的风险更大。Objective To explore the association between uterine fibroid and hyperplasia of mammary glands based on a cohort design in Chinese population. Methods A longitudinal cohort based on large population was established to follow up the outcome of hyperplasia of mammary glands. Cox proportional hazards regression model and logistic model were used to detect the association between uterine fibroid and hyperplasia of mammary glands. Results The incidence density of hyperplasia of mammary glands was 205.23/1000 person-year. Unadjusted Cox model showed that relative risk （RR） value of uterine fibroids on hyperplasia of mammary glands was 1.26 （95% CI： 1. 12-1.43, P 〈0. 001 ）. Then, after adjusting age, the RR was changed to 1.37 （95% CI： 1.21-1.55, P 〈0.001 ）. After continually adjusting the factors of overweight, drinking, smoking, sleeping quality and other risk factors, the RR was 1.36 （95% CI： 1.19- 1.55, P 〈 0. 001 ）. Logistic model showed that HR of uterine fibroids on hyperplasia of mammary glands was 1.94 （95% CI： 1.32-2. 85, P 〈 0. 001 ）. Conclusion The existence of uterine fibroids was still confirmed to be associated with hyperplasia of mammary glands after adjusting many known risk factors, suggesting that people suffering from uterine fibroids had a greater risk of hyperplasia of mammary glands.

关 键 词：乳腺增生 子宫肌瘤 关联性 COX回归 

分 类 号：R173[医药卫生—妇幼卫生保健]