人类白细胞抗原-E在宫颈癌中的表达及意义  

Expression and significance of human leucocyte antigen-E in cervical cancer

作　　者：王遥[1] 崔国英[1] 王飞[1] 李长忠[1] 

机构地区：[1]山东大学附属省立医院妇科,山东济南250021

出　　处：《山东大学学报（医学版）》2016年第9期59-63,共5页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金青年基金项目(81200426);山东省科技发展计划(2014GSF118048)

摘　　要：目的探讨人类白细胞抗原(HLA-E)蛋白在宫颈癌、宫颈高级别鳞状上皮内病变(HSIL)中的表达,及其与宫颈癌临床病理特点的关系。方法采用免疫组织化学染色检测HLA-E蛋白在18例HSIL病变宫颈组织、74例宫颈癌癌灶及其对应的20例癌旁正常宫颈组织中的表达,并评价其表达水平与宫颈癌的临床病理特点(临床分期、组织学类型、肿瘤分化程度、肿瘤直径大小、淋巴结转移、肌层浸润深度)的相关性。结果免疫组织化学染色结果显示,HLA-E蛋白在HSIL及宫颈癌患者病变组织中的表达水平明显高于癌旁正常宫颈组织(P=0.00),HLA-E蛋白在宫颈癌患者中的表达亦高于HSIL患者(P<0.01)。HLA-E蛋白的表达水平与宫颈癌的临床分期、肿瘤直径大小以及肌层浸润深度密切相关(P均<0.05),而与组织学类型、组织分化程度及淋巴结转移与否无关(P均>0.05)。结论高表达的HLA-E参与宫颈癌的免疫逃逸机制,通过改变患者的免疫状态可为宫颈癌的治疗提供新的方向和思路。Objective To explore the correlation between expression of human leucocyte antigen-E （HLA-E） in cervical cancer and the pathological features of cervical cancer and its possible role in the pathogenesis of cervical cancer. Methods The expression of HLA-E was assayed by immunohistochemical staining in 18 cases of high-grade squamous intraepithelial lesion （HSIL）, 74 cases of cervical cancer and 20 cases of adjacent normal tissues. The correlation between HLA-E expression and clinical staging, histological type, tumor differentiation, tumor size, lymph node metasta- sis, and muscle invasion was analyzed. Results Immunohistochemical staining showed the expression of HLA-E in cervical cancer and HSIL tissues were significantly higher than that in the adjacent normal cervical tissues （P = 0.01 ）, and the expression of HLA-E in cervical cancer was higher than that in the HSIL tissues （P 〈 0.01 ）. The expression of HLA-E was significantly correlated to tumor size and depth of myometrial invasion （ all P 〈 0.05 ）, but not correlated to histological type, tumor differentiation, and lymph node metastasis （ all P 〉 0.05 ）. Conclusion HLA-E expression is involved in the immune escape mechanism of cervical cancer. It may provide new directions and ideas for the treatment of cervical cancer by altering the immune status of patients.

关 键 词：人类白细胞抗原-E 宫颈肿瘤 高级别鳞状上皮内病变 免疫逃逸 

分 类 号：R711.7[医药卫生—妇产科学]