宫内缺氧对胎儿、新生儿及成年子代心脏功能的影响及相关研究进展  

Research Progress of Effect of Intrauterine Hypoxia on Cardiac Functions of Fetus,Newborn and Adult Offspring

作　　者：柴囡楠[1,2] 张昊[1] 李玲旭 王俊莹[1] 赵雅君[1] 

机构地区：[1]哈尔滨医科大学病理生理教研室,黑龙江哈尔滨150086 [2]赤峰学院医学院,内蒙古赤峰024000

出　　处：《心血管病学进展》2016年第4期401-404,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金资助项目(8170178)

摘　　要：宫内缺氧是胚胎发育中的常见综合征,多见于产前期病理生理高危妊娠,或由于血管病变使子宫血流减少,使宫内胎儿供氧减少,引起胎儿生长迟缓,严重的可引起胎儿死亡。妊娠期间慢性宫内缺氧可抑制胎儿心脏功能,改变心脏基因表达,增加心肌程序性细胞死亡,还可导致心肌细胞过早退出细胞周期和心肌肥厚,这些改变不仅在围生期表现明显,而且可能通过生理和代谢的程序化控制,引起成年子代心脏结构和功能的改变,造成成年心脏对缺血-再灌注损伤的易感性增加。现就宫内缺氧对胎儿、新生儿及成年子代心脏功能的影响及相关研究进展进行综述。Intrauterine hypoxia is a common syndrome in embryonic development,especially in prenatal period as a result of pathophysiologic high-risk pregnancy or uterine blood flow decrease due to vascular disease,consequently reducing oxygen supply to the fetus and retarding fetal growth or even causing fetus death. Chronic intrauterine hypoxia during pregnancy will inhibit fetal cardiac function,change cardiac gene expressions,increase apoptosis of myocardial cells,and also contribute to premature withdraw of myocardial cells from cell cycle and myocardial hypertrophy. These changes manifest clearly in the perinatal period,and may work via physiological and metabolic program control to change adult cardiac structures and functions as well as increase adult heart susceptibility to ischemia or reperfusion injury.Therefore,it is necessary to review both the effects of intrauterine hypoxia on cardiac functions of fetus,newborn and adult offspring with relevant research.

关 键 词：宫内缺氧 心脏功能 胎儿编程 胎儿、新生儿与成年子代大鼠 

分 类 号：R714.5[医药卫生—妇产科学]