单核细胞趋化蛋白-1-2518G/A基因多态性与结核病相关性的研究  

Research progress of correlation between chemokines MCP-1-2518G/A gene polymorphism and tuberculosis

作　　者：张金风[1] 李雨泽 褚光炎 刘书睿[1] 姜辉[1] 李殿忠[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院营养与食品卫生教研室,150081 [2]黑龙江省传染病防治院

出　　处：《结核病与肺部健康杂志》2016年第2期148-150,共3页Journal of Tuberculosis and Lung Health

基　　金：黑龙江省自然科学基金(H201451)

摘　　要：结核病是由结核分枝杆菌引起的一种传染病，其发病与否不仅取决于结核分枝杆菌的侵袭力，还与宿主的免疫能力相关。单核细胞趋化蛋白-1（MCP-1）是由CC趋化因子配体2（CCL2）所编码的一种趋化因子蛋白，其表达水平受到MCP-1．2518G／A基因多态性的调控。MCP-1在机体抗结核反应中发挥着重要作用，而且与结核病的病变程度密切相关。作者就MCP-1—2518G／A基因多态性与结核病发病的关系进行综述。Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, and the incidence de- pends not only on the invasiveness of Mycobacterium tuberculosis but also the immune system of the host. Monocyte ehemotactic protein-1 （MCP-1） is one chemokine protein encoded by CC chemokine ligand 2 gene （CCL2） and the expression level is regulated by MCP-1-2518G/A polymorphism. MCP-1 plays an important role in the body＇s anti- tuberculosis reaction and is closely related to the severity of tuberculosis. In this paper, the relationship between MCP-1-2518G/A polymorphism and the incidence of tuberculosis were reviewed.

关 键 词：单核细胞趋化蛋白11 基因多态性 结核 

分 类 号：R52[医药卫生—内科学]