原子转移自由基聚合法制备超大孔聚合物微球  

Preparation of Gigaporous Microspheres Through Atom Transfer Radical Polymerization

作　　者：虞天 许成楠 于嫄 赵飞飞[1] 潘一廷[1] 刘才[1] 黄永东[2] 张荣月[1] 

机构地区：[1]北京石油化工学院化学工程学院,北京102617 [2]中国科学院过程工程研究所生化工程国家重点实验室,北京100190

出　　处：《高等学校化学学报》2016年第9期1740-1743,共4页Chemical Journal of Chinese Universities

基　　金：北京市自然科学基金(批准号:2162013);国家自然科学基金(批准号:51103158);北京石油化工学院优秀人才培育计划项目(批准号:080318620081/037);北京高等学校高水平人才交叉培养"实培计划"项目(批准号:201507;201506);2016大学生科研训练(URT)项目(批准号:2016J00079)资助~~

摘　　要：以甲基丙烯酸缩水甘油酯为单体（GMA）、乙二醇二甲基丙烯酸酯（EDMA）为交联剂,采用原子转移自由基聚合法（ATRP）制备了PGMA-EDMA大孔聚合物微球,采用傅里叶变换红外光谱、扫描电子显微镜及压汞法对PGMA-EDMA微球进行了表征.研究结果表明,原子转移自由基聚合法制备的PGMA-EDMA微球的孔径尺寸及比表面积均大于普通自由基聚合法（CFRP）制备的PGMA-EDMA;ATRP法制备的PGMAEDMA微球的颗粒尺寸（100-400 nm）明显小于CFRP法制备的PGMA-EDMA微球的颗粒尺寸（1000 nm）.PGMA-EDMA（ATRP）的微球粒径尺寸分布优于PGMA-EDMA（CFRP）.因此PGMA-EDMA（APRP）微球在快速蛋白分离纯化方面有潜在的应用前景.The gigaporous microspheres based on a copolymer of glycidyl methacrylate and ethylene dimethacrylate were prepared by atom transfer radical polymerization（ ATRP）. The microspheres were characterized by Fourier transform infrared spectrometer,scanning electronic microscopy and mercury intrusion porosimetry.The results indicated that the microspheres by ATRP showed larger size pore and surface than those by conventional free radical polymerization（ CFRP）. It was observed from the morphology of the microspheres that the smaller size of particles（ 100—400 nm） formed the skeleton of microspheres by ATRP than CFRP method（ 1000 nm）. Meanwhile the size of these particles by ATRP was well-distributed in comparison with CFRP.These microspheres by ATRP showed good potential in rapid separation of proteins.

关 键 词：高通量 分离介质 原子转移自由基聚合 超大孔聚合物微球 

分 类 号：O632[理学—高分子化学] O658.7[理学—化学]