西甲硅油对胶囊内镜检查质量的影响  

Effects of simethicone on the quality of video capsule endoscopy examination

作　　者：黄勃[1] 王雪梅[1] 刘玉兰[1] 冯桂建[1] 尤鹏[1] 

机构地区：[1]北京大学人民医院消化科,100044

出　　处：《中华消化杂志》2016年第9期614-618,共5页Chinese Journal of Digestion

摘　　要：目的了解西甲硅油对胶囊内镜检查质量的影响。方法前瞻性研究2010年2月至2014年10月接受胶囊内镜检查的90例患者，按照接受不同剂量西甲硅油设计随机表，共分为3组。第1组口服西甲硅油15 mL，共35例；第2组口服西甲硅油30 mL，共30例；对照组未服用西甲硅油，共25例。对胶囊内镜的小肠图像进行分段评分，A段为通过幽门后1 h内的近段小肠，B段为到达回盲瓣前1 h内的远段小肠，根据肠腔内的气泡量和清洁度对A、B两段小肠评分。记录胶囊内镜在胃内、小肠内的运行时间与全小肠检查完成情况。统计学处理采用t检验，Mann-Whitney秩和检验和卡方检验。结果第1组、第2组和对照组患者A段图像加权平均分依次为0.58、0.33和1.67分，B段图像加权平均分依次为0.25、0.00和1.17分。第1组、第2组和对照组胶囊内镜的病变检查阳性率依次为68.6%（24/35）、80.0%（24/30）和52.0%（13/25），差异有统计学意义（χ^2＝8.238，P＝0.016）；第2组显著高于第1组和对照组（χ^2＝7.354、9.349，P＝0.034、0.005）。第1组、第2组和对照组小肠糜烂的检查阳性率依次为22.9%（8/35）、70.0%（21/30）和32.0%（8/25），差异有统计学意义（χ^2＝8.714，P＝0.013）；第2组显著高于第1组和对照组（χ^2＝10.600、7.380，P＝0.005、0.025）。3组间溃疡、血管畸形与黏膜隆起的检查阳性率差异均无统计学意义（P均〉0.05）。第1组、第2组和对照组病变最大径〈0.5 cm的检查阳性率为37.1%（13/35）、66.7%（20/30）和32.0%（8/25），差异有统计学意义（χ^2＝8.242，P＝0.016）；第2组显著高于第1组和对照组（χ^2＝9.250、7.842，P＝0.011、0.017）。结论应用30 mL西甲硅油可明显减少小肠气泡量，提高胶囊内镜的检查阳性率。Objective To investigate the effects of simethicone on the quality of video capsule endoscopy （VCE） examination. Methods A prospective study was performed in 90 patients received VCE examination from February 2010 to October 2014. The randomized table was set according to different dosage of simethicone the patients received, by which patients were divided into three groups. Group 1 （35 cases） received 15 mL simethieone, group 2 （30 cases） received 30 mL simethicone and control group （25 cases） received no simethicone. The small intestinal visualization quality of VCE was scored by segments. Segment A was proximal small intestine （one hour after VCE passing pylorus）. Segment B was distal small intestine （one hour before VCE passing ileocecal valve）. Segment A and B were scored according to the air bubbles and degree of cleanliness. Gastric transit time, small bowel transit time and VCE completion rate were recorded. Student＇s t test, Mann-Whitney rank sum test and chi square test were performed for statistical analysis. Results The average scores of segment A of group 1, group 2 and control group were 0.58, 0.33 and 1.67, respectively, and the average socres of segment B were 0.25, 0.00 and 1.17, respectively. The lesion detection rates of group 1,group 2 and control group were 68.6 % （24/35）, 80.0% （24/30） and 52. 0% （13/25）, respectively, and the differences was statistically significant （χ^2= 8. 238, P= 0. 016）. The detection rate of group 2 was significantly higher than those of group 1 and control group （χ^2= 7. 354 and 9.349,P=0.034 and 0.005）. The detection rates of small intestinal erosion of group l,group 2 and control group were 22.9% （8/35）, 70.0% （21/30） and 32.0%（8/25）, respectively, and the differences was statistically significant （χ^2 = 8. 714, P〈 0. 013）. The detection rate of group 2 was significantly higher than those of group 1 and control group （χ^2 = 10. 600 and 7. 380,P=0. 005 and 0. 025）. There was no statistically sig

关 键 词：西甲硅油 胶囊内镜检查 小肠气泡量 运行时间 检查阳性率 

分 类 号：R444[医药卫生—诊断学]