2009—2014年寿光市新生儿乙型肝炎疫苗免疫后5年效果分析  

Effects of immunization 5 years later with hepatitis B vaccine for newborns in Shouguang,2009-2014

作　　者：刘中芹 王晓琼[1] 刘召红[1] 王颖[1] 崔佳[1] 

机构地区：[1]山东省寿光市疾病预防控制中心,山东寿光262700

出　　处：《现代预防医学》2016年第17期3144-3146,共3页Modern Preventive Medicine

基　　金：国家科技重大专项艾滋病和病毒性肝炎等重大传染病防治专项"乙型肝炎病毒免疫预防新策略的研究"中的"初免低/无应答人群随访研究及慢性肝病患者乙肝疫苗接种效果等研究"(2012ZX10002001)

摘　　要：目的观察新生儿乙型肝炎疫苗免疫后5年预防效果。方法对完成3剂次5μg酿酒酵母乙肝疫苗接种及免后抗体检测者5年后进行随访调查,定量检测乙肝表面抗原抗体(抗-HBs)、乙肝核心抗体(抗-HBc)。结果对初免应答抗-HBs≥100m IU/ml且无乙肝疫苗再接种史的577名儿童检测结果分析,抗-HBs阳性377例、阳性率65.34%,几何平均滴度(GMT)37.75 m IU/ml±88.37 m IU/ml,无乙肝表面抗原(HBs Ag)阳性者。与5年前的初免后检测结果比较,抗-HBs阳性率下降34.66%,年均递减8.16%;GMT下降91.58%,年均递减40.08%。出生体重重、初免应答水平高5年后抗-HBs阳性率高于出生体重轻、初免应答水平低者。结论基因重组乙肝疫苗免疫后5年,免疫效果良好,存在较好的免疫持久性和保护效果。出生体重与初免应答水平可能影响免疫持久性。Objective To observe the preventive effects and correlation factors of newborns with hepatitis B vaccination 5 years later. Methods Follow - up investigation on completing 3 doses of 5p, g yeast hepatitis B vaccination and detection of antibodies in 5 years later were carried out,and the detection of hepatitis B surface antigen antibody （anti -HBs） and hepatitis B core antibody （anti - HBe） was taken quantitatively. Results The detection results of 577 children were analyzed,who the initial immunity response against - HBs ≥ 100 mlU/ml and no hepatitis B vaccine history again. 377 cases were anti - HBs positive,with the positive rate 65.34% ,and the GMT was 37.75 mIU/ml ±88.37 mIU/ml. No case was positive on hepatitis B surface antigen （HBsAg）. Compared with the results after primary immunization 5 years ago,the positive rate of anti - HBs fell by 34.66% , with an average annual decline rate of 8. 16% . Meanwhile, GMC decreased by 91.58% , with an average annual decline rate of 40.08%. Birth weight and initial immunity response level were the factors of influencing anti - HBs lasting effects. Conclusion 5 years after vaccination, the immune effect is good, and the immunization persistence and protection work well. Birth weight and initial immunity response level are the influencing factors of immunization persistence.

关 键 词：新生儿 乙型肝炎疫苗 乙肝病毒表面抗体 免疫效果 

分 类 号：R179[医药卫生—妇幼卫生保健]