新生儿缺氧缺血脑病(HIE)采用四己糖唾液酸神经节甘脂治疗的疗效观察  

作　　者：赵志军 

机构地区：[1]陕西省宝鸡市陇县人民医院儿科,陕西宝鸡721200

出　　处：《临床医药文献电子杂志》2016年第27期5475-5476,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的新生儿缺氧缺血脑病（HIE）采用四己糖唾液酸神经节甘脂治疗的疗效分析。方法选取我院儿科2014年1月～2015年7月收治的新生儿缺氧缺血脑病（HIE）患儿90例,随机分为对照组和研究组,对照组使用HIE常规综合疗法进行治疗,研究组患儿常规治疗的前提下加用四己糖唾液酸神经节甘脂进行治疗,对比两组患儿的疗效和神经行为评分（NBNA评分）以及后遗症的发生情况差异。结果研究组的治疗总有效率为95.56%,明显高于对照组的82.22%,治疗后一年内,前者后遗症的发生率为6.67%,低于后者的20.00%,差异有统计学意义（P〈0.05）;两组患儿在治疗前NBNA评分没有差异,治疗后研究组患儿的NBNA评分（38.0±6.6）明显高于对照组的（33.1±4.7）,差异有统计学意义（P〈0.05）。结论四己糖唾液酸神经节甘脂配合常规治疗对于HIE病情的治疗有着良好的效果,低后遗症、高治疗效率,值得推广应用。Objective Hypoxic-ischemic encephalopathy （HIE） with four sialic acid hexose ganglion monoglyceride therapy clinical effectiveness analysis. Methods Pediatric hospital admitted from January 2014 to July 2015 period 90 cases of neonatal hypoxic-ischemic encephalopathy （HIE）infants were randomly divided into two groups,the use of HIE conventional combination therapies,research group of children under the premise of conventional therapy plus four sialic acid hexose ganglion monoglyceride treatment,comparing the efficacy and neurobehavioral scores of two groups of children （NBNA score）,serum S10013,glycolytic enzyme enolase （NSE） levels and the incidence of sequelae differences. Results The study group,the total effective rate was 95.56% significantly higher than 82.22%,within one year after treatment,the incidence of sequelae of the former 6.67% lower than 20.00% of the latter,P〈0.05;children Study Group NBNA score （38.0±6.6） was significantly higher than that of （33.1±4.7）,and serum levels of NSE former S100β were （2.97±0.36）,（8.25±1.21） is lower than the latter （5.77±1.30）, （14.32±2.07）,P〈0.05. Conclusion Four sialie acid hexose ganglion monoglyceride with conventional treatment for HIE disease treatment has a good effect,low sequelae,high treatment efficiency, should be widely applied.

关 键 词：新生儿缺血缺氧脑病 四己糖唾液酸神经节甘脂 疗效 

分 类 号：R722.1[医药卫生—儿科]