术中自体血回输对异位妊娠患者术后炎症反应的影响  

Influence of intraoperative autologous blood transfusion on postoperative inflammatory reaction in patients with ectopic pregnancy

作　　者：王英[1] 杨文丽[1] 时卉丽[2] 

机构地区：[1]廊坊市第四人民医院妇产科,河北廊坊065700 [2]河北省血液中心

出　　处：《临床血液学杂志（输血与检验）》2016年第4期623-625,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:探讨自体血回输对异位妊娠术后炎症反应的影响。方法:选择2013-01-2015-08 169例异位妊娠大出血手术患者为研究对象。根据患者是否同意以及是否符合自体血回输适应证,分为自体血回输组93例和异体血输注组76例。记录2组术中失血量、术中回收血量、异体血输入量、输血反应及术后伤口感染发生率。检测术前、术后1d及5dC-反应蛋白(CRP)、红细胞沉降率(ESR)、白细胞介素-6(IL-6)、干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)等炎症反应指标。结果:1自体血回输组的异体血输注量、输血反应和术后感染率明显低于异体血输注组(P<0.05)。2与术前相比,2组术后CRP和ESR均明显升高(P<0.05),自体血回输组升高幅度低于异体血输注组(P<0.05);与术前相比,2组术后IL-6明显升高(P<0.05),自体血回输组升高幅度高于异体血输注组(P<0.05);异体血输注组IFN-γ术后1d明显下降,术后5d恢复至术前水平,自体血回输组术后5d IFN-γ明显升高;2组术后TNF-α浓度与术前比较无明显变化(P>0.05)。结论:自体血回输患者比异体血输注患者术后炎症反应轻。Objective：To investigate the influence of intraoperative autologous blood transfusion on postoperative inflammatory reaction in patients with ectopic pregnancy.Method：A total of 169 cases of patients with ectopic pregnancy were included in this study in the Fourth People＇s Hospital of Langfang City between January 2013 and August 2015.According to whether the patients agreed and the indications of autologous blood transfusion,all patients were divided into autologous blood transfusion group（n=93）and allogeneic blood infusion group（n=76）.Blood loss,volume of autogeneic blood collection,volume of allogeneic blood transfusion,adverse reactions of blood transfusion and the incidence of wound infection were recorded in two groups.Inflammation indexes such as CRP,ESR,IL-6,IFN-γand TNF-αwere tested at preoperative,postoperative 1dand 5d.Result：1The volume of allogeneic blood transfusion,incidences of blood transfusion adverse reaction and postoperative wound infection in autologous blood transfusion group were significantly less than those in allogeneic blood infusion group（P〈0.05）.2 Compared with the preoperative,postoperative ESR and CRP were significantly increased（P〈0.05）in two groups,the increased degrees in autologous blood transfusion group was lower than those in allogeneic blood transfusion group（P〈0.05）.Compared with the preoperative,IL-6on the first and 5th day after operation in two groups increased significantly（P〈0.05）,and the increased degree in autologous blood transfusion group was higher than that in allogeneic blood transfusion group（P〈0.05）.IFN-γrised significantly on the 5th day after operation in autologous blood transfusion group,but decreased significantly on the first day after operation and returned to preoperative level in allogeneic blood transfusion group.Compared with the preoperative,postoperative TNF-αwas no obvious change in two groups.Conclusion：The postoperative inflammatory reaction of patients with autologous blood transfusion may b

关 键 词：自体血回输 异位妊娠 炎症反应 

分 类 号：R457.1[医药卫生—治疗学]