戊巴比妥钠在小型猪无气管插管麻醉中的应用研究  

Applied research of the pentobarbital sodium in miniature pigs without endotracheal intubation anesthesia

作　　者：范文桔 李佩丰 刘刚[2] 霍仲超 梁倩菲 莫德扬 陈长升[2] 钟铮[2] 

机构地区：[1]南宁市第二人民医院泌尿外科,广西530031 [2]广西壮族自治区人民医院泌尿外科,南宁530021 [3]广西壮族自治区江滨医院重症医学科,南宁530021

出　　处：《中国临床新医学》2016年第8期676-679,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金资助项目(编号:2014GXNSFAA118183);广西卫计委科研课题(编号:Z2015306)

摘　　要：目的探讨戊巴比妥钠在制备小型猪无气管插管模型中的麻醉效果及安全性。方法将20头小型猪随机分成A组(n=10)和B组(n=10)。A组予3%戊巴比妥钠注射液,B组予5%氯胺酮注射液进行无气管插管全身麻醉,并施行相同手术。观察麻醉及手术效果、生命征和不良反应。结果两组的麻醉及手术效果均满意。A、B组的诱导时间分别为(10.76±1.50)min、(8.73±1.15)min,差异有统计学意义(P<0.05);两组的体重、呼吸频率、心率、肛温、脉搏血氧饱和度及复苏时间差异均无统计学意义(P>0.05);A组未见明显不良反应,B组麻醉过程中可见唾液分泌较多、肌张力高及咀嚼现象,且术中有1例出现呕吐;两组均无死亡。结论两种药物均可用于小型猪无气管插管麻醉,麻醉时间及深度可以灵活控制,且戊巴比妥钠还具有不良反应较少、经济、安全、获取方便等优点。Objective To explore the efficacy and safety of the pentobarbital sodium in the miniature pig anesthetic model without endotracheal intubation. Methods Twenty miniature pigs were randomly divided into group A（ n = 10） and group B（ n = 10）. Group A was given 3% pentobarbital sodium injection,and group B was given 5%ketamine injection to perform anesthesia and the same operation without endotracheal intubation. The anesthetic effect,surgical effect,vital signs and adverse reactions were compared between the two groups. Results The anesthetic and surgical effects were satisfying in both of the two groups. The induction time of group A was significantly longer than that of group B[（ 10. 76 ± 1. 50） vs（ 8. 73 ± 1. 15） ]. There were no significant differences between the two groups in the weight,breathing rate,heart rate,anal temperature,pulse,oxygen saturation,and recovery time（ P〉0. 05）. No obvious adverse reactions were found in group A. There were some adverse reactions in group B during the anesthesia,including more secretion of saliva,higher muscle tension and chew phenomenon,and intraoperative vomiting in one case. No dead case was found in the two groups. Conclusion Both pentobarbital sodium and ketamine can be used for anesthesia in the miniature pigs without endotracheal intubation. Pentobarbital sodium is more safe,economic and convenient for the anesthesia.

关 键 词：小型猪 无气管插管麻醉 戊巴比妥钠 氯胺酮 

分 类 号：R614[医药卫生—麻醉学]