夫西地酸对寻常痤疮患者皮损表皮葡萄球菌和痤疮丙酸杆菌的体外抗菌作用研究  

In vitro antibacterial activity of fusidic acid cream against Staphylococcus epipermidis and Propionibacterium acnes isolates from acne vulgaris lesions

作　　者：高诗燕[1] 路永红[1] 陈涛[1] 王珊珊[1] 何丽莎[1] 单雨婷 周培媚[1] 瓦庆彪[1] 吴波[1] 李林[1] 陈前明[1] 保勇[2] 尹亚菲[2] 陆玲[2] 

机构地区：[1]成都市第二人民医院遵义医学院附属成都医院皮肤科,610017 [2]成都市第二人民医院遵义医学院附属成都医院检验科,610017

出　　处：《中华皮肤科杂志》2016年第9期658-659,共2页Chinese Journal of Dermatology

基　　金：成都市卫生局科研课题（2014010）;CALM-澳美中国研究基金（痤疮研究）

摘　　要：目的 探讨2%夫西地酸乳膏对寻常痤疮皮损中表皮葡萄球菌和痤疮丙酸杆菌的体外抗菌活性。方法 用琼脂扩散法作药敏试验，比较夫西地酸和莫匹罗星对表皮葡萄球菌和痤疮丙酸杆菌的体外抗菌活性。结果 夫西地酸和莫匹罗星对表皮葡萄球菌的抑菌环直径分别为（31.76 ± 6.05）和（31.98 ± 17.20） mm，差异无统计学意义（t = 0.132，P 〉 0.05），对痤疮丙酸杆菌的抑菌环直径分别为（18.15 ± 3.24）和（3.00 ± 0.00） mm，差异有统计学意义（t = 24.27，P 〈 0.05）。结论 夫西地酸体外对寻常痤疮患者皮损中的优势菌株表皮葡萄球菌和痤疮丙酸杆菌有较强的抗菌作用。Objective To investigate the in vitro antibacterial activity of fusidic acid cream against Staphylococcus epipermidis and Propionibacterium acnes isolates from acne vulgaris lesions. Methods The agar diffusion method was used to evaluate the antibacterial activity of fusidic acid cream and mupirocin ointment against S. epipermidis and P. acnes isolates from acne vulgaris lesions in vitro. Inhibition zone diameters were measured and compared between the two topical drugs. Results A significant difference was observed between the fusidic acid cream and mupirocm ointment in the inhibition zone diameters for P. acnes （18.15 ± 3.24 vs. 3.00 ± 0.00 mm, t = 24.27,P 〈 0.05）, but not in those for S. epidermidis （31.76 ± 6.05 vs. 31.98 ± 17.20 mm, t = 0.132, P 〉 0.05）. Conclusion Fusidic acid cream displays strong in vitro antibacterial activity against S. epidermidis and P. acnes isolates from acne vulgaris lesions.

关 键 词：寻常痤疮 梭链孢酸 痤疮丙酸杆菌 表皮葡萄球菌 微生物敏感性试验 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]