蛇床子素固体脂质纳米粒的体内抗肿瘤活性研究  

Study on the Anti-tumor Activities of Osthol Solid Lipid Nanoparticles

作　　者：陈娇婷[1] 叶民珠[1] 

机构地区：[1]赣南医学院,江西赣州341000

出　　处：《中国民族民间医药》2016年第17期22-24,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:制备蛇床子素固体脂质纳米粒(ost-SLN),并考察ost-SLN体内的抗肿瘤活性。方法:采用熔融-匀化法制备蛇床子素固体脂质纳米粒,评价Ost-SLN对小鼠H22肝癌实体瘤的抑瘤作用,观察对脾、胸腺等器官的损伤情况,比较不同浓度下对机体带来的影响。结果:ost-SLN可不同程度地抑制H22荷瘤小鼠的肿瘤生长,而且随着给药浓度增加,ost-SLN的抑瘤率均上升,分别为34.2%、50.9%、68.5%。结论:ost-SLN在体内均有明显的抗肿瘤活性,且未出现毒性反应,有望开发成一种高效、低毒的蛇床子素制剂。Objective To prepare osthol Solid lipid nanoparticles （ost -SLN ） and study on its antitumor activities in vivo. Methods Ost-SLNwere prepared with melt-homogenization,In vivo,The mice liver cancer （H22 ） were selected and implanted in Kun Ming mice,Tumor inhibitory percentage,thymus gland and spleen indexes were measured.Results Ost-SLNS inhibited the H22 hepatoma-bearing mice in different degrees,and the inhibitory rate of ost＂SLN were 34.2%,50.9% and 68.5%,respectively, demonstrating a drug-dose dependent effect.Conclusion Ost-SLN had obvious anti-tumor activities in vivo,and did not reveal any toxic effects in experimental animals with the administered doses.It＇s a potential carriermaterial in developing a high performance ost nanometer system with low toxicity.

关 键 词：蛇床子素 ost-SLN 抗肿瘤 

分 类 号：R285.5[医药卫生—中药学]