胸腺素治疗慢性阻塞性肺疾病急性加重的临床观察及其对患者免疫功能的影响  

Clinical effect of thymosin in the patients with AECOPD and its influence on patient's immune function

作　　者：谢宁[1] 周磊[2] 唐扣明[1] 

机构地区：[1]复旦大学附属中山医院青浦分院药剂科,上海201700 [2]复旦大学附属中山医院青浦分院呼吸科,上海201700

出　　处：《世界临床药物》2016年第9期616-620,624,共6页World Clinical Drug

摘　　要：目的观察胸腺素治疗慢性阻塞性肺疾病急性加重(AECOPD)的临床疗效及其对患者免疫功能的影响。方法本院呼吸科2013年1月至2015年1月住院部及门诊部收治的100例AECOPD患者纳入本研究,并根据数字盲法随机分为对照组和观察组,各50例,同期于本院接受健康体检的50例设为健康对照组。两组AECOPD患者均接受呼吸内科常规治疗,其中观察组在基础治疗上加用胸腺素肌内注射,每周3次,两组疗程均为2周。比较两组AECOPD患者症状、体征的消失时间、住院时间以及三组治疗前后外周血Th1、Th2细胞百分率。结果 1与对照组比较,观察组AECOPD患者喘憋消失时间、咳嗽好转时间、湿啰音消失时间、干啰音消失时间以及住院时间均明显缩短,且各指标组间差异均具有统计学意义(P<0.05)。2治疗前,两组AECOPD患者Th1细胞百分率均较健康对照组降低(P<0.05),且两组间差异无统计学意义(P>0.05);治疗后,两组AECOPD患者Th1细胞百分率均有所提升,且观察组提高幅度明显高于对照组(P<0.05),但两组均仍低于健康对照组(P<0.05)。Th2细胞百分率比较,两组AECOPD患者治疗前后均与健康对照组无明显差异(P>0.05)。3治疗后,两组AECOPD患者Th1/Th2比值有所升高,其中观察组升高趋势更为显著。结论胸腺素可以显著改善AECOPD患者的临床症状,其机制可能与Th1/Th2比值上调有关。Objective To observe clinical effect of thymosin in the patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD） and its influences on patient＇s immune function.Methods A total of 100 patients with AECOPD in our hospital from 2013 January to 2015 January were divided into observation group and control group（each group n=50） according to digital blind method.Another 50 cases from physical examination were selected as healthy control group.All AECOPD patients were given the routine treatment of department of respiratory,and the observation group was additionally treated with thymosin injection three times a week.The whole course of treatment was two weeks.The symptoms,signs of disappearance time,length of stay in hospital of both two AECOPD groups and peripheral blood Th1,Th2 cell percentage in three groups were measured and compared.Results（1）In observation group,the breathe heavily and suffocation disappearance time,cough disappearance time,moist rales and dry rales improvement time,length of stay in hospital were obviously shorter than those in control group,the differences were statistically significant（P〈0.05）.（2）Before treatment,the percentages of Thl cells in both two AECOPD patients groups were lower than those in healthy control group（P〈0.05）,and there was no statistical difference between two groups（P〈0.05）.After treatment,the percentages of Thl cells in AECOPD patients groups were all increased,but still lower than those in healthy control group（P〈0.05）.The percentages of Thl cells in observation group was significantly higher than that in control group（P〈0.05）.The percentages of Th2 cells in both two AECOPD patients groups were no significant difference from those in healthy control group in any time（P〉0.05）.（3）The Th1/Th2 cell ratios in both two AECOPD patients groups were increased after treatment,and the ratio in observation group was more obvious.Conclusion Thymosin therapy can improve the curative effect in the treat

关 键 词：慢性阻塞性肺疾病急性加重(AECOPD) 胸腺素注射液 TH1 TH2 

分 类 号：R563[医药卫生—呼吸系统] R979.5[医药卫生—内科学]