健康中老年人血清胱抑素C参考区间探讨  

Establishment of reference ranges for serum cystatin C in healthy middle-aged and elderly Chinese individuals

作　　者：胡勤辛[1] 叶雄伟[1] 沈世恩[1] 谢海锋[1] 于小妹[1] 

机构地区：[1]浙江医院检验科,杭州310013

出　　处：《中华老年医学杂志》2016年第9期990-992,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨我国健康中老年人血清胱抑素c（Cys-C）的参考区间。方法采用血清透射比浊方法测定连续收集的1087例相对健康中老年人血清Cys-C水平。提供的方法利用频度分析和柱状图分析所得数据建立95％的参考区间。结果依据美国临床实验室标准化协会（CLSI）C28-A2指南按临床实验室参考值范围的定义和确认第2版（CLSIC28-A2）进行分析，1087例中老年人Cys-C的水平分布在0．30～1.55mg／L；中老年男性Cys-C水平均高于女性（z=-10．19，P〈0．01）。Cys-C水平均随着年龄的增加而升高（R=0．600，P〈0．01）。不同年龄组Cys-C水平相比较差异均有统计学意义（χ2=411．17，P〈0．01）。Cys-C95％参考区间按年龄组50～、55～、60～、65～、70～、75～岁，男性分别为0．42～0．98mg／L、0.45～1．04mg／L、0.47～1．34mg／L、0.46～1．38mg／L、0．61～1．33mg／L、0．61～1．28mg／L；女性分别为0．39～0．94mg／L、0.42～1．02mg／L、0.40～0．91mg／L、0.46～1.03mg／L、0．57～1．04mg／L、0．55～1．27mg／L。结论本研究初步建立了本地区50岁及以上相对健康中老年人血清Cys-C的参考区间。为中老年人群体的相关疾病的诊断及疗效观测提供相应参数。Objective To establish normal reference ranges for serum cystatin C（Cys C）in relatively healthy middle aged and elderly（〉50 years）Chinese individuals. Methods A total of 1087 candidates were consecutively selected and serum Cys C levels were measured by transmission turbidimetry. Frequency analysis and histogram were used to establish the 95% confidence reference range according to methods provided by CLSI （C28-A2）. Results Based on the definition and verification procedures for clinical laboratory reference ranges （CLSI C28 A2, second edition）, Cys C levels of 1087 participants fell within the range of 0.30-1.55 mg/L; Male participants had higher serum Cys-C levels than female participants（Z=- 10.19 ,P〈0.01）. The serum Cys-C level increased with age, regardless of gender（R = 0. 600, P〈 0.01 ）. Differences in Cys-C levels between age groups were statistically significant （χ2= 411.17,P〈0.01）. The reference ranges of normal serum Cys-C levels for different age groups（50-, 55 -, 60 -, 65 -, 70 -, 75 -,） were 0.42-0. 98mg/L, 0. 45- 1.04mg/L, 0. 47-1.34mg/L, 0. 46-1. 38mg/L, 0. 61-1.33mg/L, 0.61-1.28 mg/L, respectively, for males,and 0.39 0. 94mg/L,0. 42-1. 01mg/L,0. 40-0. 91mg/L,0. 46-1. 03mg/L,0. 57-1. 04mg/L,0. 55 1.27mg/L,respectively,for females. Conclusions This study established preliminary normal serum Cys-C reference ranges for healthy middle-aged and elderly（〉 50 years）individuals in this region, which can serve as parameters for disease diagnosis and treatment evaluation.

关 键 词：胱抑素C 参考值 

分 类 号：R446.1[医药卫生—诊断学]