利用光纤导入的组织内光动力疗法治疗45例面部中-重度痤疮  

Use of optical fiber imported intra-tissue photodynamic therapy for treatment of 45 patients with facial moderate to severe acne

作　　者：刘伟[1] 袁丹 王倩[1] 程石[1] 闫凯[1] 李福民[1] 薛竞[1] 林新瑜[1] 陈金[1] 段西凌[1] 林昭春[1] 

机构地区：[1]四川省医学科学院.四川省人民医院,四川成都610072 [2]西南医科大学,四川泸州646000

出　　处：《实用医院临床杂志》2016年第5期104-107,共4页Practical Journal of Clinical Medicine

基　　金：四川省科研院所科技成果转化资金项目(编号:14010134)

摘　　要：目的 观察5-氨基酮戊酸（ALA）光纤导入红光组织内照射治疗45例面部中-重度痤疮的临床疗效及安全性。方法 面部中-重度痤疮患者45例,予ALA光纤导入红光于痤疮皮损部位进行组织内照射,每次5 min,每7~10天治疗一次,共6次;在第4次、第6次治疗后及治疗完成后的第4、8、16周进行疗效判断,并记录治疗时及治疗后不良反应的发生情况。结果 共44例完成治疗,1例因色素沉着退出试验。第4次、第6次治疗后及治疗结束后随访的第4、8、16周,有效率分别为86.4%、90.9%、88.6%、88.6%及86.4%;治疗时不良反应发生总数110次,治疗后不良反应发生总数123次。结论 ALA光纤导入红光组织内照射是一种治疗面部中-重度痤疮疗效理想,不良反应轻微的新方法。Objective To investigate the clinical efficacy and safety of optical fiber irradiation 5-aminolevulinic acid （ALA） photodynamic therapy for treatment of 45 patients with facial moderate to severe acne. Methods We used an intra-tissue irradiation- importing red light directly into the target lesion with optical fiber to treat 45 patients with facial moderate to severe acne. Each treatment lasted 5 rain. All patients received irradiation every 7 to 10 days for a total of 6 irradiations. Treatment effects and adverse reactions were recorded after the 4th and 6th irradiation, and at 4,8 and 16 weeks after the entire treatment. Results Forty-four patients completed the treatment and 1 case existed because of the heavy pigmentation. After the 4th and 6th irradiation and at 4,8 and 16 weeks, efficiencies were 86.4% ,90. 9% ,88.6% ,88.6% and 86. 4% ,respectively. There were 110 adverse reactions recorded during treatment and there were 123 adverse reactions recorded after the treatment. Conclusion The optical fiber irradiation 5-aminolevulinic acid photodynamic therapy is a relatively safe and effective new method for moderate to severe acne.

关 键 词：痤疮 光化学疗法 氨基酮戊酸 光导纤维 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]