救必应酸在大鼠体内的口服生物利用度研究  

Oral Bioavailability Study of Rotundic Acid in Rats

作　　者：南敏伦[1] 赫玉芳[1,2] 赵昱玮 吕娜[3] 司学玲 李阔[3] 何忠梅[3] 

机构地区：[1]吉林省中医药科学院,长春130012 [2]吉林修正药业新药开发有限公司 [3]吉林农业大学

出　　处：《中国药师》2016年第9期1648-1650,共3页China Pharmacist

基　　金：国家自然科学基金面上项目(编号:31470418)

摘　　要：目的:研究救必应酸在大鼠体内药动学和口服生物利用度。方法:建立测定大鼠血浆中救必应酸浓度的RP-HPLC法。考察大鼠经灌胃和尾静脉给予40 mg·kg^(-1)的救必应酸后血药浓度变化。采用3p97软件计算分析药动学参数和口服生物利用度。结果:灌胃组大鼠的Cmax为(0.81±0.22)μg·ml^(-1),Tmax为(45.24±5.13)min,T1/2为(101.47±8.25)min,AUC为(76.3±13.68)μg·min-1·ml^(-1);静脉注射组的T1/2为(73.68±11.02)min,AUC为(1 687.4±29.54)μg·min^(-1)·ml^(-1)。救必应酸口服利用度为4.52%。结论:救必应酸的口服生物利用度较差。Objective： To study the pharmacokinetics and oral bioavailability of rotundic acid in rats. Methods： A RP-HPLC method was established to determine rotundic acid in the plasma of rats, and the changes of plasma concentration after the oral or intravenous administration of 40 mg·kg^-1 rotundic acid were investigated. 3p97 Software was used to calculate and analyze the pharmaco- kinetic parameters and oral bioavailability. Results： In the oral group, Cmax was （ 0.81± 0.22 ） μg·ml^-1, Tmax was （45.24 ±5.13 ） min, T1/2 was （ 101.47 ± 8.25 ） rain and AUC was （76.3 ± 13.68）μg·min^-1·ml^-1. In the intravenous group, Tl/2 was （73.68 ±11.02）min and AUC was （ 1 687.4 ±29.54） μg·min^-1·ml^-1. The oral bioavailabi]ity of rotundic acid was 4.52%. Conclusion： The oral bioavailability of rotundic acid is relative poor.

关 键 词：救必应酸 反相高效液相色谱法 药动学 口服生物利用度 

分 类 号：R969.1[医药卫生—药理学]