生物黏附给药系统黏附性能的体外评价方法的研究进展  

Research Progress in Experimental Methods for the Evaluation of Adhesion Property of Bioadhesive Drug Delivery Systems in vitro

作　　者：吕琳[1] 王国杰[2] 何晓明[2] 杜青[2] 党云洁[2] 

机构地区：[1]天津泰达国际心血管病医院药剂科,天津300270 [2]河北医科大学药学院

出　　处：《中国药师》2016年第9期1752-1755,共4页China Pharmacist

基　　金：河北省自然科学基金项目青年基金(编号:H2016206584);河北医科大学2013科研骨干人才培育计划项目(编号:20130142);河北省高等学校科学技术研究项目(编号:QN20131011)

摘　　要：生物黏附给药系统通过黏附性的高分子材料延长药物在用药部位的滞留时间来促进药物的吸收,提高药物的生物利用度。由于黏附性能与缓控释效果和药物吸收密切相关,因此评价生物黏附给药系统的黏附性能具有重要意义。本文总结了近年来用于生物黏附给药系统的生物黏附性能的体外评价方法,包括最小剥离力测定法、黏膜组织表面留存量测定法、黏膜组织表面黏附滞留时间测定法、溶胀性能测定法和流体黏度测定法等,并对其中部分评价方法的操作进行简述。Bioadhesive delivery systems with sustained release characteristics can promote the absorption and increase the bioavailability of drugs by prolonging the residence time on the applied site. The evaluation of adhesion property of bioadhesive drug delivery systems is important because the sustained release effect and the absorption are closely related with the adhesion. The methods for the evaluation of the adhesive properties of bioadhesive drug delivery systems in vitro were summarized in the article, including determining the minimum peel force, measuring the residues on mucosa surface, determining the retention time on mucosal surface, measuring the swelling and the viscosity of fluid and so on, and the operation of some methods were described simply as well.

关 键 词：生物黏附给药系统 黏附性能 体外评价 

分 类 号：R945[医药卫生—微生物与生化药学]