氟比洛芬酯脂微球注射液的配伍稳定性考察  

Study on Compatibility Stability of Flurbiprofen Axetil Lipid Microspheres Injection

作　　者：朱钰婷 倪坚军[1] 蔡鑫君[1] 徐颖颖[1] 周峰[1] 

机构地区：[1]浙江省中西医结合医院药剂科,杭州310003

出　　处：《中国药师》2016年第9期1781-1782,共2页China Pharmacist

基　　金：浙江省中医药科技计划项目(编号:2012ZA101);浙江省中西医结合学会科研项目(编号:2012LY017);杭州市红会医院院内课题(编号:hhyn201205)

摘　　要：目的:考察氟比洛芬酯脂微球注射液与0.9%氯化钠注射液、5%葡萄糖注射液的配伍稳定性,为临床应用提供理论依据。方法:测定在25℃避光条件下5 h内氟比洛芬酯脂微球注射液与0.9%氯化钠注射液或5%葡萄糖注射液配伍液的外观、氟比洛芬酯脂微球的粒径及氟比洛芬酯的含量变化;测定氟比洛芬酯脂微球注射液冻融前后与0.9%氯化钠注射液配伍液的外观及氟比洛芬酯脂微球的粒径变化。结果:在25℃避光条件下放置5 h,各配伍液的外观、粒径和含量无明显变化;氟比洛芬酯脂微球注射液冻融前后的配伍液外观和粒径亦无明显变化。结论:氟比洛芬酯脂微球注射液在0.9%氯化钠注射液、5%葡萄糖注射液中配伍后,5 h内于避光条件下可稳定共存。Objective： To investigate the stability of flurbiprofen axetil lipid microspheres injection combined with 0.9% sodium chloride injection or 5% dextrose injection, and provide theoretical basis for the clinical application. Methods： The content changes of flurbiprofen axetil in the mixture of flurbiprofen axetil lipid microspheres injection and 0.9% sodium chloride injection or 5% dextrose injection were determined in 5 h at 25 ℃ away from light, and the changes in the appearance and particle size of flurbiprofen axetil lipid microspheres were investigated. The changes in the appearance and particle size of flurbiprofen axetil lipid microspheres in the mixture of flurbiprofen axetil lipid mierospheres injection and 0.9% sodium chloride injection before and after freezing and thawing were also investigated. Results： The appearance, particle size and content had no significant changes in all mixtures in 5 h at 25℃ away from light. The appearance and particle size of flurbiprofen axetil lipid microspheres in the mixture before and after freezing and thawing had no significant changes as well. Conclusion： The mixture of flurbiprofen axetil lipid microspheres injection and 0.9% sodium chloride injection or 5% dextrose injection is stable in 5 h away from light.

关 键 词：氟比洛芬酯脂微球注射液 配伍 稳定性 

分 类 号：R942[医药卫生—药剂学]