巴戟肉、盐巴戟天调节阳虚内寒证大鼠能量代谢的比较研究  

Effect of Morinda officinalis Root and Its Salt-Processing Product on Energy Metabolism in Rats with Yang Deficiency

作　　者：黄玉秋[1] 范亚楠[1] 贾天柱[1,2] 耿彤彤 史辑[1,2] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]国家中医药管理局炮制原理解析重点研究室/辽宁省中药炮制工程技术研究中心,辽宁大连116600

出　　处：《中药材》2016年第5期1028-1031,共4页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金青年基金(81001635);国家自然科学基金(81473350)

摘　　要：目的:比较不同剂量巴戟肉、盐巴戟天对阳虚內寒证大鼠能量代谢的影响,探讨巴戟天补肾壮阳的作用机制,为巴戟天的临床合理应用提供科学依据。方法:采用甲巯咪唑灌胃给药的方法制备阳虚内寒证模型,分别给予巴戟肉、盐巴戟天2种炮制品高、中、低浓度的水煎液,以右归丸为阳性对照药,以肝糖元、肌糖元、游离脂肪酸(NEFA)、脂蛋白脂酶(LPL)、肝脂酶(HL)、肝脏和骨骼肌Na+,K+-ATP酶、Ca2+,Mg2+-ATP酶、琥珀酸脱氢酶(SDH)以及体脂系数等为评价指标。结果:巴戟肉和盐巴戟天对阳虚内寒证大鼠的能量代谢均有一定的改善作用,盐巴戟天较相同剂量的巴戟肉好,治疗效果更为显著。结论:巴戟天的补肾壮阳作用与调节能量代谢有关,在临床使用中应注意对炮制品的选择和剂量的应用。Objective： To compare the effects of Morinda officinalis root and its salt-processing prodduct on rats with kidney yang deficiency from the viewpoint of energetic metabolism. Methods： The rat models for the kidney yang deficiency were established through the perfusion of methimazole. The models were treated with different dosages of Morinda officinalis root without woods and its salt-processing products extracts. The activity of liver glycogen,muscle glycogen,free fatty acid（ NEFA）,lipoprotein lipase（ LPL）,hepatic lipase（ HL）,liver and skeletal muscle Na＋,K＋ATPase,Ca2 ＋,Mg2 ＋ATPase,succinodehydrogenase（ SDH） were measured by colormetric methods,and the coefficient of body fat were observed by weighing method. Results： Morinda officinalis root without woods and its saltprocessing products could improve the energetic metabolism of kidney yang deficiency of rats. The effects of salt-processing products were better than Morinda officinalis root without woods in the same dosage. Conclusion： The effect of invigorating the kidney and strengthening yang of Morinda officinalis were correlated with energetic metabolism. The correct processing-products of Morinda officinalis root should be chosen with the suitable measurements in clinic.

关 键 词：巴戟肉 盐巴戟天 阳虚内寒证 能量代谢 补肾助阳 

分 类 号：R283.1[医药卫生—中药学] R285.5[医药卫生—中医学]