血管组织工程的发展现状和趋势  

Advances in vascular tissue engineering

作　　者：方俊 李松 

机构地区：[1]Department of Bioengineering,University of California-Los Angeles

出　　处：《医用生物力学》2016年第4期333-339,共7页Journal of Medical Biomechanics

基　　金：美国NIH资助项目(R01HL121450;R01HL117213)

摘　　要：心脑血管疾病是全球发病率和死亡率最高的疾病,其主要病因是动脉粥样硬化。临床上主要采用血管移植物重建病损血管,人造合成血管在大口径血管修复中取得了满意的效果,但在小口径血管修复中效果并不理想。近30年来,血管组织工程发展极其迅速,从再生的角度为血管修复提供了新的途径。本文综述血管组织工程的最新进展(体外、体内、原位血管组织工程),并对未来发展趋势进行了前瞻性展望。Cardiovascular diseases such as atherosclerosis remain the leading cause of morbidity and mortality in the world. The replacement of large diameter vessels （ ≥6 mm）, such as the aorta, has been performed suc- cessfully with synthetic non-degradable vascular grafts, while it is still a challenge to engineer small diameter vessels with long-term patency. Over the past three decades, the rapid progress in the field of vascular tissue engineering has provided some promising approaches, including in vitro, in vivo, and in situ tissue engineering of vascular grafts. This review is focused on the most recent progress and trends in vascular tissue engineering.

关 键 词：血管组织工程 组织工程 原位再生 

分 类 号：R318.01[医药卫生—生物医学工程]