清利活血解毒汤治疗湿热蕴结型痛风性关节炎的疗效观察  

Clinical Efficacy of Qingli Huoxue Jiedu Tang on Damp-heat Accumulation Type Gouty Arthritis

作　　者：王宏莉[1] 邓田莲[1] 唐先平[1] 

机构地区：[1]中国中医科学院望京医院,北京100102

出　　处：《中国实验方剂学杂志》2016年第18期140-143,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：中国中医科学院望京医院院级科研课题(WJYY2014-YY-010)

摘　　要：目的:观察清利活血解毒汤治疗湿热蕴结型痛风性关节炎的临床疗效,并探讨其作用机制。方法:将90例湿热蕴结型痛风性关节炎患者随机分为2组,治疗组60例,对照组30例。治疗组给予清利活血解毒汤(早晚各1次,口服)+洛索洛芬钠片(60 mg/天,口服,bid)治疗;对照组给予洛索洛芬钠片(60 mg/天,口服,bid)治疗,连续观察2周。观察服药前后两组中医证候积分、关节疼痛及肿胀症状改善时间,记录血沉(ESR),C-反应蛋白(CRP),尿酸(UA),视觉模拟评分法(VAS)疼痛评分,15 m步行时间疗效指标及血、尿常规,肝肾功安全性指标和其他不良反应。结果:治疗组在中医症状有效率、疼痛肿胀改善时间,VAS评分,UA,CRP,ESR,15 m步行时间上改善均优于对照组(P<0.05,P<0.01),且无明显不良反应。结论:清利活血解毒汤治疗湿热蕴结型痛风性关节炎能较快缓解关节红肿热痛等临床症状,改善关节活动度,同时具有降低尿酸及炎症指标作用。Objective： To observe the clinical efficacy of Qingli Huoxue Jiedu Tang on damp-heat accumulation type gouty arthritis,and explore its action mechanism. Method： The 90 patients with damp-heat accumulation type gouty arthritis were randomly divided into treatment group（ 60 cases） and control group（ 30cases）. Patients in treatment group were treated with Qingli Huoxue Jiedu Tang（ once in the morning and evening by oral taking） ＋ loxoprofensodium tablets（ 60 mg po,bid）,patients in control group were treated with loxoprofensodium（ 60 mg po,bid）. Patients were observed for 2 weeks in both groups. The traditional Chinese medicine（ TCM） syndrome scores,and the hours of reducing swelling of joint pain were observed,erythrocyte sedimentation rate（ ESR）,C-reactive protein（ CRP）,uric acid（ UA）,visual analogue scale（ VAS）,15 meters walking time,routine blood test,routine urine test,safety indexes of liver and kidney functions and other adverse reactions were recorded. Result： The improvement in TCM syndrome scores,the hours of reducing swelling of joint pain,ESR,CRP,UA,VAS,and 15 meters walking time in treatment group was better than that in control group（ P 0. 05,P 0. 01）,and no adverse reaction was present in treatment group. Conclusion： Qingli Huoxue Jiedu Tang can quickly relieve joint swelling,pain and other symptoms,improve joint range of motion,reduce uric acid and inflammatory indexes.

关 键 词：清利活血解毒 痛风性关节炎 湿热蕴结型 血沉 C-反应蛋白 尿酸 

分 类 号：R287[医药卫生—中药学]