扶正抗毒丸联合HAART疗法对HIV感染ⅡB期患者氧化应激反应的影响  

Effects of Fuzheng Kangdu Pills Combined with HAART Therapy on Oxidative Stress in Patients with HIV Infection Stage ⅡB

作　　者：李钦[1,2] 王莉[1] 马兰[3] 

机构地区：[1]云南省中医中药研究院,昆明650223 [2]成都中医药大学,成都610075 [3]昆明医科大学第二附属医院,昆明650101

出　　处：《中国实验方剂学杂志》2016年第18期144-148,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金地区项目(81360583)

摘　　要：目的:探讨扶正抗毒丸联合高效抗反转录病毒治疗(HAART)疗法对人类免疫缺陷病毒(HIV)感染ⅡB期患者氧化应激反应的干预作用,并探讨其机制。方法:采用随机数字表法将120例患者随机分为空白组,HAART组,扶正抗毒丸+HAART组,最终获得完整数据资料的患者94例,其中空白组30例,HAART组33例,扶正抗毒丸+HAART组31例,疗程均为12个月,观察扶正抗毒丸联合HAART疗法对HIV感染ⅡB期患者活性氧(ROS),核转录因子-κB(NF-κB),T淋巴细胞亚群绝对计数及病毒载量的作用。结果:治疗12个月时,扶正抗毒丸+HAART组患者ROS,NF-κB含量显著低于空白组和HAART组(P<0.05);HAART组、扶正抗毒丸+HAART组与空白组比较,能有效增加病毒载量<100 copy·m L-1的患者例数(P<0.01),减少病毒载量波动例数(P<0.01),两组比较无统计学差异;CD3+T淋巴细胞计数显示,扶正抗毒丸+HAART组与治疗前、空白组和HAART组比较明显增加(P<0.05,P<0.01);HAART组、扶正抗毒丸+HAART组患者CD4+T淋巴细胞计数与治疗前和空白组比较明显增加(P<0.05),扶正抗毒丸+HAART组CD4+T淋巴细胞计数与HAART组比较有增加的趋势。结论:扶正抗毒丸联合HAART疗法能较好的减少HIV感染ⅡB期患者氧化应激反应的发生作用和有效抑制NF-κB含量增加。同时,还能有效增加血浆病毒载量<100 copy·m L-1的患者例数,减少病毒载量波动例数和升高CD3+,CD4+T淋巴细胞计数。Objective： To explore the interventional effects of Fuzheng Kangdu pills combined with highly active antiretroviral therapy（ HAART） therapy on oxidative stress in patients with human immunodeficiency virus（ HIV） infection stage IIB,and investigate its action mechanism. Method： The 120 patients were randomly divided into blank group,HAART group,and Fuzheng Kangdu pills ＋ HAART group by using the random number table. Complete data were obtained from 94 of these patients,including 30 cases in the blank group,33 cases in HAART group,and 31 cases in Fuzheng Kangdu pills ＋ HAART,patients in all the groups received treatment for12 months to observe the effects of Fuzheng Kangdu pills ＋ HAART on reactive oxygen species（ ROS）,nuclearfactor-κB（ NF-κB）,and absolute counts of the T lymphocyte subsets in patients with HIV infection stage ⅡB.Result： At 12 months of treatment,ROS and NF-κB levels in Fuzheng Kangdu pills ＋ HAART group were significantly lower than those in blank group and HAART group（ P 0. 05）,as compared to blank group,both HAART group and Fuzheng Kangdu pills ＋ HAART group could effectively increase the number of patients with viral load 100 copy·m L- 1（ P 0. 01） and reduce the number of patients with viral load fluctuation（ P 0. 01）,which however presented no significant differences between the two groups. CD3＋T lymphocytes counts in the Fuzheng Kangdu pills ＋ HAART group were significantly increased as compared with the conditions before treatment,blank group or HAART group（ P 0. 05,P 0. 01）. CD4＋T lymphocyte counts in HAART group and Fuzheng Kangdu pills ＋ HAART group were significantly increased as compared with the conditions before treatment or blank group（ P 0. 05）,CD4＋T lymphocyte count in Fuzheng Kangdu pills ＋ HAART group showed an increasing tendency as compared with that in HAART group. Conclusion： Fuzheng Kangdu pills combined with HAART therapy could reduce oxidative stress and effectively inhibit NF-κB level elevation in pa

关 键 词：扶正抗毒丸 高效抗反转录病毒治疗法 人类免疫缺陷病毒感染ⅡB期 氧化应激 干预作用 

分 类 号：R287[医药卫生—中药学]