肥胖儿童血清脂肪细胞因子水平与糖脂代谢、微炎症状态的关系  

Relationship of serum adipocytokine levels with glycolipid metabolism and micro-inflammatory state in obese children

作　　者：赵申[1] 骆强 

机构地区：[1]湖北文理学院附属襄阳市中心医院儿科,湖北襄阳441000 [2]湖北省襄阳市中医医院儿科,湖北襄阳441000

出　　处：《海南医学院学报》2016年第19期2335-2338,共4页Journal of Hainan Medical University

基　　金：湖北省教育厅科学研究计划资助项目(D2011820)~~

摘　　要：目的:分析肥胖儿童血清脂肪细胞因子水平与糖脂代谢、微炎症状态的关系。方法:299例肥胖患儿及264例正常儿童纳入本次研究,抽取空腹外周静脉血测定血清脂肪细胞因子、糖脂代谢及微炎症相关指标水平,进一步分析肥胖儿童的脂肪细胞因子水平与糖脂代谢、微炎症相关指标水平的相关关系。结果:观察组血清瘦素(leptin)、Vaspin水平高于对照组儿童,脂联素(APN)水平低于对照组(P<0.05);血清空腹胰岛素(FINS)、C-P、皮质醇(Cor)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平高于对照组,高密度脂蛋白胆固醇(HDL-C)水平低于对照组(P<0.05);血清超敏C反应蛋白(hs-CRP)、白介素-8(IL-8)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平高于对照组(P<0.05);血清leptin、APN、Vaspin水平与以上糖脂代谢及微炎症状态指标水平均存在直接相关关系。结论:肥胖儿童存在炎症因子高表达、糖脂代谢紊乱,过度表达的脂肪细胞因子可能是肥胖持续存在并加重的重要因素。Objective： To analyze the relationship of serum adipocytokine levels with glycolipid metabolism and micro- inflammatory state in obese children. Methods： A total oF 299 cases of obese children and 264 cases of normal children were in- cluded in the study, fasting peripheral venous blood was extracted to determine serum levels of adipocytokines, glucolipid me- tabolism and micro-inflammation-related indexes, and the correlation between the levels of adipocytokines and the levels of glu- colipid metabolism and micro-inflammation-related indexes was further analyzed. Results： Serum Leptin and Vaspin levels of observation group were significantly higher than those of control group, and APN level was significantly lower than that of con- trol group （P〈0.05） ; serum FINS, C-P, Cor, TG and LDL-C levels were significantly higher than those of control group,and HDL-C level was significantly lower than that of control group （P〈0.05）; serum hs-CRP, IL-8, IL-6 and TNF-α levels were significantly higher than those of control group （P〈0.05） ; serum Leptin, APN and Vaspin levels were directly correlated with the levels of above glucolipid metabolism and micro-micro-inflammatory state indexes. Conclusions.. There are high ex- pression levels of inflammatory factors and glucolipid metabolism disorder in obese children, and excessively expressed adipocy- tokines may be the important factors of persist and worsened obesity.

关 键 词：肥胖儿童 脂肪细胞因子 糖脂代谢 微炎症状态 

分 类 号：R723.14[医药卫生—儿科]