2型糖尿病和糖尿病肾病人群的中医证候演变规律  

Evolution rules of TCM syndrome of patients with type 2 diabetes and diabetic nephropathy

作　　者：牟新[1] 周迪夷[1] 庄爱文[2] 刘颖慧[1] 陈慧萍[1] 胡永宾[1] 寿成珉[1] 陈家炜[1] 周旦阳[1] 

机构地区：[1]杭州市红十字会医院,杭州310003 [2]浙江省中医药研究院,杭州310007

出　　处：《中华中医药杂志》2016年第9期3707-3710,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.30801467;No.81273623);浙江省科技厅项目(No.2013C33212);中国博士后课题基金(No.2014M551775)~~

摘　　要：目的:通过对糖尿病肾病和2型糖尿病患者人群进行流行病学及中医证候学的调查、分析,探讨2型糖尿病和糖尿病肾病人群的中医证候演变规律。方法:本研究利用《糖尿病肾病中医证候量表》对符合纳入标准的400例2型糖尿病和237例糖尿病肾病患者人群进行了横断面调查研究,采用聚类分析对中医证型的演变规律进行分析和归纳。结果:根据中医证候分布情况,糖尿病和糖尿病肾病均为本虚标实之证,糖尿病本虚以气阴两虚为主,标实以火热证为主;糖尿病肾病在此基础上,以阳虚更为明显,逐渐发展为阴阳两虚,瘀血证贯穿病程始终。结论:对同一疾病的不同病程阶段分别采用聚类分析进行证候学研究,这种思路和方法对探讨证候演变具有一定的实践意义。Objective：To study evolution rules of traditional Chinese medicine（TCM） syndrome of patients with type 2 diabetes and diabetic nephropathy（DN） through the epidemiological investigation and analysis.Methods：The cross-sectional study included 237 DN patients and 400 type2 diabetic patients based on the TCM Syndrome Scale of Diabetic Nephropathy and cluster analysis was used to analyze and conclude the evolution rules of TCM syndromes.Results：The two diseases were both dei ciency in root and excess in branch.Qi and yin dei ciency with inner heat was the basic characteristic of diabetes and diabetic nephropathy was more likely to be characterized by yang dei ciency which would gradually develop into yin and yang dei ciency with blood stasis throughout the course.Conclusin：Using clustering analysis to study TCM syndromes at different stages of the same disease has certain practical significance in exploring the evolution of syndromes.

关 键 词：糖尿病肾病 2型糖尿病 聚类分析 四诊信息 中医证候 

分 类 号：R259[医药卫生—中西医结合]