原发性高血压患者血清salusin-β和脂联素水平联合预测其高血压急症的价值  

Value of serum salusin-β combined with adiponectin level in forecast of hypertensive emergency of patients with essential hypertension

作　　者：冯奕习 郑碧英[2] 彭伟如 

机构地区：[1]广东省东莞市中医院检验科,广东东莞523005 [2]广东医科大学基础医学院微生物学教研室,广东东莞523808 [3]广东省东莞市中医院输血科,广东东莞523005

出　　处：《中国医药科学》2016年第15期143-145,共3页China Medicine And Pharmacy

摘　　要：目的探讨原发性高血压血清salusin—β和脂联素（ADP）水平联合预测其高血压急症的价值。方法选取2015年1月～2016年1月我院收治的普通原发性高血压患者39例作为A组，24例原发性高血压合并高血压急症发作的患者为B组，另选取同期健康体检者45例作为c组，采用酶联免疫法检测并比较三组受试者血清中的salusin—β和脂联素水平，并采用ROC曲线分析血清salusin—β和脂联素水平联合预测原发性高血压患者高血压急症的价值。结果与c组相比，A组血清salusin—β水平较高，脂联素水平则较低；与A组相比，B组血清salusin—β水平较高，脂联素水平则较低，差异比较具有统计学意义（P〈0．05）。曲线分析结果显示，血清salusin—β和脂联素水平预测高血压急症的ROC曲线下面积、灵敏度、特异度均较血清salusin—β、脂联素水平单独预测高血压急症的ROC曲线下面积、灵敏度、特异度高，差异有统计学意义（P〈0．05）。结论原发性高血合并高血压急症患者血清salusin—β明显较高，脂联素水平则明显偏低，联合检测原发性高血压患者血清salusin—β和脂联素水平对其高血压急症具有较好的预测价值，可作为原发性高血压患者高血压急症预测的有效参考指标。Objective To explore the value of serum salusin-β combined with adiponectin （ADP） level in forecast of hypertensive emergency of patients with essential hypertension. Methods 39 cases of patients with essential hypertension cured in our hospital from January 2015 to January 2016 were selected as group A, 24 cases of patients with essential hypertension combined with hypertensive emergency were selected as group B, and 55 health examine person during the same period were selected as group C. Euzymelinked immunosorbent assay was used to detect to compare the serum salusin- β and adiponectin （ADP） level of the three groups. ROC curve was used to analyze the value of serum salusin- β combined with adiponectin level in forecast of hypertensive emergency of patients with essential hypertension. Results Compared with group C, the serum salusin- β level of group A was higher, and adiponectin （ADP） level was lower. Compared with group A, the serum salusin- β level of group B was higher, and adiponectin （ADP） level was lower. The differences were statistically significant （P 〈 0.05）. Curve analysis results showed that area of ROC curve, sensitivity and specificity of serum salusin- β combined with adiponectin （ADP） level in forecast of hypertensive emergency were higher than those of serum salusin-β, adiponectin （ADP） level alone in forecast of hypertensive emergency. And the difference was statistically significant （P 〈 0.05）. Conclusion Serum salusin- β serum salusin- β of hypertensive emergency of patients with essential hypertension is higher, and adiponectin （ADP） level is significantly lower. Serum salusin- β combined with adiponectin （ADP） level in forecast of patient with essential hypertension has a good predictive value for its hypertensive emergency. It can be as an effective reference index for the forecast of hypertension emergency of patients with essential hypertension.

关 键 词：高血压 salusin—p 脂联素 预测 高血压急症 

分 类 号：R544.1[医药卫生—心血管疾病]