自制护脉胶囊对葡萄糖耐量异常患者早期实施抗氧化治疗的研究  

Acupotomy Therapys Effect and Mechanism in Knee Osteoarthritis

作　　者：陈卓[1] 曹天理 张勇[1] 陈炯[1] 钟兴菊[1] 谭静宇[1] 彭波[1] 

机构地区：[1]绵竹市人民医院,四川绵竹618200

出　　处：《世界中医药》2016年第B06期1628-1629,共2页World Chinese Medicine

基　　金：四川省卫生厅科研课题立项（编号：110583）

摘　　要：目的探讨联合使用护脉胶囊对葡萄糖耐量异常患者早期进行抗氧化治疗的临床研究。方法：将80例患者随机分为两组，每组各40例，两组患者均实施糖尿病健康教育，采取糖尿病饮食运动方案，定期监测患者血糖，治疗组同时联合护脉胶囊；检测患者治疗前及治疗6个月后炎性标记物（CRP、TNF-α、IL-6）、内膜一中层厚度（IYT）、颅内血管收缩峰血流速度（Vp）及舒张末期血流速度（Vd）、搏动指数（PI）变化情况，并进行统计分析。结果：两组患者治疗前炎性标记物、IMT、PI值情况均无差异（P〉0．05）；治疗6个月后两组的炎性标记物均较治疗前有显著性降低（P〈0．01），IGT组优于对照组（P〈0．05）；CDFI检测两组患者IMT值均较治疗前明显改善，组间比较IGT组有显著性差异（P〈0．05）；TCD检测患者颅内血管Vp、Vd、PI值均较治疗前有所改善，IGT组血流改善情况明显优于对照组（P〈0．01），且IGT组PI值下降情况优于对照组。结论：采用自制护脉胶囊对IGT患者实施早期抗氧化治疗能有效减轻患者血管炎性反应、改善血管粥样硬化，这对于延缓缺血性卒中的发生是积极可行的临床治疗方案。Objective：To observe the effect of Acupotomy therapy on pain and quality of life in patients with osteoarthritis,and the biomechanical balance and inflammatory factors of Acupotomy mechanism.Methods：During January 2014 to October 2015,total 60 knee osteoarthritis cases in department of acupuncture,orthopaedics and in-patient of our hospital were divided into into Acupotomy group and control group according to visiting sequence numbers and single blind randomized digital table method,each group with 30 cases.Patients in control group received sodium hyaluronate injection into the knee joint cavity,Acupotomy group treated by Acupotomy therapy based on the control groups treatment.Pain visual simulation score （VAS）was used to evaluate of Acupotomy therapys effect on pain,and the quality of life table （36 items short form health survey scale,the SF 36）was used to assess the life quality of the patients after treatment.Through the measurement of femoral angle,tibial angle,femoral and tibial angle,LT/LP value （value of patella and patellar ligament length （LT）maximum diagonal length （LP）ratio）and LT/HI （the ratio of patellar liga-ment length （LT）and tibial notch height （HI））,Acupotomy treatment of knee joint biomechanics balance effect was observed. Combined with the detection of articular cavity effusion tumor necrosis factor alpha （TNF-alpha）,the synergy of the mechanism of Acupotomy treatment for osteoarthritis of the knee was observed.Results：The VAS score in acupotomy group became significantly lower after the treatment （t =-9.063 P =0.001 〈0.05）.Compared with the control group,the VAS score of Acupotomy group was significantly lower （t =-7.811 P =0.003 〈005）.After treatment,the SF-36 scale scores in 8 dimensions of acupotomy group significantly improved,compared with the score before treatment of acupotomy group and the score of control group after treatment, the differences were significant （P 〈0.01）.There were no significant differences on femora

关 键 词：护脉胶囊 葡萄糖耐量异常 抗氧化治疗 

分 类 号：R587.1[医药卫生—内分泌]