氧化应激与男性不育研究进展  

Oxidative Stress in Male Infertility

作　　者：刘建国 赵红乐 金保方[2] 

机构地区：[1]陕西省中医医院男科,陕西西安710003 [2]东南大学附属中大医院中西医结合男科,江苏南京210009

出　　处：《中华中医药学刊》2016年第9期2104-2106,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81273760);陕西省自然科学基金项目(2016JQ8034);陕西省中医药管理局项目(2015-JC012)

摘　　要：氧化应激可以破坏精子质膜的流动性,损伤精子核内DNA的完整性,影响精子的质量和功能;氧化应激还能改变细胞功能,引起生精细胞凋亡增加。氧化应激亦会引起类固醇合成相关酶的活性下降,影响睾酮的合成和代谢,从而影响男性的生殖功能。氧化应激损伤是男性不育的重要因素,进一步研究氧化应激损伤的具体机制,对于指导男性不育的治疗具有积极意义。Oxidative stress can damage the fluidity of the sperm plasma membrane and the integrity of DNA in the sperm nucleus,leading to the decline in sperm quality and function. Oxidative stress can also increase the apoptosis of germ cells and decrease the synthesis of testosterone by inhibiting the activity of steroidogenic enzymes. Oxidative stress is an important factor for male infertility. Further study on the mechanism of oxidative stress is of positive significance for the treatment of male infertility.

关 键 词：氧化应激 男性不育 精子损伤 细胞凋亡 类固醇激素合成 

分 类 号：R698.2[医药卫生—泌尿科学]