风免一号方联合西药治疗阴虚内热型系统性红斑狼疮  

No.1 Rheumatism and Immunology Prescription Combined Western Medicine Therapy for Internal Heat due to Yin Deficiency Type of Systemic Lupus Erythematosus

作　　者：陈薇薇[1] 苏晓[1] 杨旭鸣[1] 唐华燕[1] 夏嘉[1] 江春春[1] 

机构地区：[1]上海中医药大学附属上海市中医医院风湿病科,上海200071

出　　处：《中华中医药学刊》2016年第9期2201-2204,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：上海市第三批中医临床优势专科(风湿科)项目(ZYSNXD-YL-CTXK)

摘　　要：目的:评价风免一号方联合西药治疗阴虚内热型系统性红斑狼疮(SLE)的临床疗效。方法:将中医辨证为阴虚内热型轻度及中度活动的SLE患者随机分为治疗组与对照组各30例。两组均给予醋酸泼尼松片加硫酸羟基氯喹作为基本用药。治疗组再给予风免一号方加霉酚酸酯片。对照组再给予霉酚酸酯片。中药每日1剂,分两次煎汤,每次100 m L口服;霉酚酸酯片750 mg,每日2次口服。两组均以24周为1个疗程,疗程结束后观察两组患者的SLE疾病活动指数(SLE-DAI)积分、中医证侯评分、血沉、24 h尿蛋白定量、免疫指标[免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、补体C3(C3)、补体C4(C4)]与抗体[抗双链DNA(抗ds-DNA)]的变化以及并发症的发生率。结果:两组患者临床疗效比较:治疗组显效2例,有效23例,无效5例,对照组显效0例,有效17例,无效13例。治疗后两组中医证候积分、SLE-DAI积分组内比较,治疗组的差异有统计学意义(P<0.01);组间比较,治疗组中医证候积分改善优于对照组,差异有统计学意义(P<0.01)。治疗后两组组内比较,治疗组IgG、IgA差异有统计学意义(P<0.05)、治疗组IgM、C3差异有显著统计学意义(P<0.01);组间比较,治疗组IgG、C3改善优于对照组,差异有统计学意义(P<0.05)。治疗后两组组内比较,治疗组24 h尿蛋白定量、抗ds DNA抗体的差异有统计学意义(P<0.05)、对照组血沉、抗dsDNA抗体的差异有统计学意义(P<0.05);组间比较,治疗组24 h尿蛋白定量、抗ds DNA抗体改善优于对照组,差异有统计学意义(P<0.05)。治疗组并发症事件的总发生率与对照组比较有显著性差异(P<0.05)。结论:采用风免一号方联合西药治疗轻中度活动期系统性红斑狼疮(阴虚内热型)疗效确切,并发症发生少。Objective：To evaluatethe clinical curative effect of No. 1 Rheumatism and Immunology Prescription com- bined with western medicine treatment of Yin deficiency type of systemic lupus erythematosus （SLE）. Methods ： The mild and moderate active SLE patients of internal heat due to Yin deficiencysyndrome were randomly divided into treatment group and control group,30 cases in each. The two groups were given prednisone acetate tablets plus hydr0xychloroquine sulfate as basic drugs. The treatment group received No. 1 Rheumatism and Immunology Prescription combined with my- cophenolate mofetil tablets. The control group received mycophenolate mofetil tablets. Chinese medicine：one dose a day, every time lO0mL orally. Mycophenolate mofetil tablets 750mg,twice a day orally. 24 weeks was a course of treatment. At the end of treatment,we observed the changes of SLE - DAI integral, traditional Chinese medicine syndrome score, e- rythrocyte sedimentation rate （ESR）, 24 hour urinary protein, immune index [ immunoglobulin protein G （IgG）, immuno- globulin M protein （IgM） ,immunoglobulin protein A （ IGA ） and complement C3 （ C3 ）, C4 （ CA, ） and antibody （ anti double stranded DNA （ anti dsDNA） ] and the incidence of complications. Results： The clinical efficacy of the two groups：in the treatment group ,2 cases were markedly effective ,23 caseseffective ,5 casesineffective. The control group ：0 case was markedly effective, 17 caseseffective, 13 casesinvalid. After treatment, two groups＇ TCM syndrome integral and SLE - DAI integral groupwere statistically significant （ P 〈 0.01 ）. The treatment group＇ s were improved significantly bet- ter than the control group＇ s and the difference was statistically significant （P 〈 0.01 ）. After treatment, the treatment group＇ s IgA and IgG had significance（ P 〈 0.05 ）. And IgM and C3 had significant difference. The treatment group＇ sIgG and C3were better than those in the control group （P 〈 0.05）. The treatment gro

关 键 词：风免一号方 阴虚内热 系统性红斑狼疮 

分 类 号：R593.241[医药卫生—内科学]