慢性乙型肝炎患者胃黏膜损伤中胃黏液sIgA的变化研究  

Change of gastric mucus sIgA in chronic hepatitis B patients complicated with gastric mucosal injury

作　　者：樊巧 冯红军[2] 周环宇 张璇涛 巴金甫 

机构地区：[1]平高集团有限公司医院内科,河南平顶山467001 [2]平顶山市第一人民医院消化内科,河南平顶山467000

出　　处：《中华医院感染学杂志》2016年第17期3892-3894,共3页Chinese Journal of Nosocomiology

基　　金：河南省科技厅基金资助项目(201309832X)

摘　　要：目的对胃黏液sIgA在慢性乙型肝炎病毒(HBV)感染合并胃黏膜损伤患者中的变化进行研究,为临床诊治提供参考依据。方法选取2013年10月-2015年10月医院诊治的40例慢性乙型肝炎病毒感染合并胃黏膜损伤患者为试验组,另选同期入院的40例慢性胃炎患者为对照组;采用放射免疫法测定胃黏液sIgA水平,分析两组患者胃黏液sIgA的变化。结果慢性乙型肝炎病毒合并胃黏膜损伤患者胃黏液sIgA水平显著高于对照组(P<0.05),慢性乙型肝炎、肝硬化以及慢性重症肝炎患者随着病情的加重,胃黏液sIgA水平呈下降趋势,同时ALT、PTA水平也呈现下降趋势,TBIL水平出现上升趋势,两组患者差异有统计学意义(P<0.05);不同类型慢性HBV感染患者中胃黏膜血清白蛋白(ALB)差异无统计学意义。结论慢性乙型肝炎患者合并胃黏膜损伤发生率较高,且肝损伤越严重胃黏膜损伤发生率越高,胃黏液sIgA可能参与乙型肝炎患者胃黏膜病变,是其影响因素之一。OBJECTIVE To investigate the change of gastric mucus sIgA in chronic hepatitis B virus infection patients complicated with gastric mucosal injury so as to provide guidance for clinical diagnosis and treatment.METHODS Totally 40 chronic hepatitis B virus infection patients complicated with gastric mucosal injury who were treated in hospitals from Oct 2014 to Oct 2015 were assigned as the experimental group,and 40 patients with chronic gastritis who were hospitalized during the same period were set as the control group.The level of gastric mucus sIgA was determined by using radioimmunoassay,and the change of the gastric mucus sIgA was observed and compared between the two groups of patients.RESULTS The level of gastric mucus sIgA of the experimental group was significantly higher than that of the control group（P〈0.05）.With the aggravation of illness condition,the level of gastric mucus sIgA of the patients with chronic hepatitis B,liver cirrhosis,or chronic severe hepatitis showed downward trend,the levels of ALT and PTA also showed downward trends,and the level of TBIL showed upward trend,and there was significant difference between the two groups of patients（P〈0.05）.There was no significant difference in the gastric mucus serum albumin（ALB）among the patients with different types of chronic HBV infection.CONCLUSION The incidence of gastric mucosal injury is high in the patients with chronic hepatitis B;the severer the liver damage,the higher the incidence of gastric mucosal injury is.The gastric mucus sIgA may involve in the gastric mucosal lesions of the patients with hepatitis B,and it is one of the influencing factors.

关 键 词：胃黏液sIgA 慢性乙型肝炎 病毒感染 胃黏膜损伤 

分 类 号：R512.62[医药卫生—内科学]