HBV与HCV感染手术患者红细胞免疫参数变化研究  

Changes of erythrocyte immune parameters of HBV,HCV infection patients receiving surgical procedures

作　　者：杨之丽[1] 冯丹[1] 何位忠[1] 毛跃红[1] 袁能华[1] 彭笳宸[2] 

机构地区：[1]遵义医学院附属医院手术室,贵州遵义563003 [2]遵义医学院附属医院骨一科,贵州遵义563003

出　　处：《中华医院感染学杂志》2016年第17期3906-3908,共3页Chinese Journal of Nosocomiology

基　　金：贵州省科学技术基金资助项目(黔科合J字2010-2182)

摘　　要：目的观察乙型肝炎病毒(HBV)及丙型肝炎病毒(HCV)感染手术患者红细胞免疫参数的变化,为该类患者治疗及干预措施的制定提供依据。方法选取2014年1月-2015年11月医院进行手术治疗的30例HBV感染患者为A组,同期手术治疗的30例HCV感染患者为B组,30例无HBV及HCV感染手术患者为C组,将3组患者的术前及术后1d的红细胞免疫指标及红细胞参数指标进行比较。结果术前A组与B组的红细胞免疫指标中的免疫黏附促进因子(FEER)、免疫黏附抑制因子(FEIR)、协同肿瘤红细胞花环率(ATER)及自然肿瘤红细胞花环率(NTER)水平分别为(45.21±4.68)%、(33.46±3.57)%、(43.22±3.87)%、(1.05±0.15)%及(45.40±4.72)%、(33.38±3.46)%、(43.21±3.90)%、(1.10±0.14)%,均差于C组的(55.45±5.20)%、(27.21±2.56)%、(56.56±4.83)%、(1.78±0.20)%,A组及B组红细胞参数均高于C组,术后1dA组及B组的红细胞免疫指标及红细胞参数指标也均差于C组,差异有统计学意义(P<0.05)。结论手术患者HBV及HCV感染的红细胞免疫红细胞参数变化明显,且术前及术后均差异明显,故应进行针对性干预。OBJECTIVE To observe the changes of erythrocyte immune parameters of HBV,HCV infection patients receiving surgical procedures so as to provide guidance for treatment and put forward the intervention measures.METHODS Totally 30 patients with HBV infection who received surgical procedures in the hospital from Jan 2014 to Nov 2015 were chosen as the group A,meanwhile,30 patients with HCV infection who received surgical procedures were set as the group B,and 30 patients without HBV or HCV infection were assigned as the group C.The erythrocyte immune parameters and erythrocyte parameter indexes were observed and compared among the three groups of patients before the surgery and after the surgery for 1day.RESULTS As for the erythrocyte immune parameters,the immunoadhesins promoting factor（FEER）of the group A and the group B were respectively（45.21±4.68）% and（45.40±4.72）%,lower than（55.45±5.20）% of the group C;the immune adherence inhibiting factor（FEIR）of the group A and the group B were respectively（33.46±3.57）% and（33.38±3.46）%,higher than（27.21±2.56）% of the group C;the collaborative tumor erythrocyte rosette rate（ATER）of the group A and the group B were respectively（43.22±3.87）% and（43.21±3.90）%,lower than（56.56±4.83）% of the group C;the natural tumor erythrocyte rosette rate（NTER）of the group A and the group B were respectively（1.05±0.15）% and（1.10±0.14）%,lower than（1.78±0.20）% of the group C.The erythrocyte parameters of the group A and the group B were higher than those of the group C;the erythrocyte immune parameters and erythrocyte parameter indexes of the group A and the group B were lower than those of the group C after the surgery for 1day（P〈0.05）.CONCLUSIONThe erythrocyte immune parameters of the HBV,HCV infection patients undergoing the surgical procedures change remarkably,and there is significant difference before and after the surgery,therefore,it is necessary to take targeted interventions.

关 键 词：手术患者 HBV及HCV感染 红细胞免疫 红细胞参数 

分 类 号：R181.32[医药卫生—流行病学]