胸腰椎压缩性骨折老年患者肺部感染对CRP、IL-2和TNF-α的影响及预后分析  

Influence of pulmonary infection on CRP,IL-2,and TNF-α of elderly patients with thoracolumbar compression fractures and analysis of prognosis

作　　者：邢林卿[1] 武永娟[1] 田明波[1] 马利阁[1] 张保龙[1] 尹万乐[1] 李达[1] 尤笑迎[1] 

机构地区：[1]郑州人民医院骨关节外科,河南郑州450000

出　　处：《中华医院感染学杂志》2016年第17期3972-3974,共3页Chinese Journal of Nosocomiology

基　　金：河南省科学技术基金资助项目(20139809G)

摘　　要：目的探讨胸腰椎压缩性骨折老年患者肺部感染对C-反应蛋白(CRP)、白细胞介素-2(IL-2)、肿瘤坏死因子(TNF-α)的影响及预后,为临床治疗提供参考依据。方法选择2012年1月-2015年8月100例胸腰椎压缩性骨折老年患者作为研究对象,观察肺部感染发生情况,并分析肺部感染对CRP、IL-2及TNF-α的影响,随访1年分析肺部感染对骨折预后的影响。结果老年胸腰椎压缩性骨折100例患者中,有20例发生肺部感染,感染率20.0%;感染患者CRP水平为(14.46±2.27)mg/L、IL-2水平为(3.41±0.80)pg/L、TNF-α水平为(18.48±3.45)pg/ml,均明显高于非感染患者(7.04±2.78)mg/L、(2.51±0.68)pg/L、(12.51±2.63)pg/ml,差异均有统计学意义(P<0.05);随访1年感染组骨折愈合率为60.0%,明显低于非感染患者的81.3%,差异有统计学意义(P<0.05)。结论肺部感染可增高胸腰椎压缩性骨折老年患者CRP、IL-2及TNF-α水平,影响胸腰段压缩性骨折老年患者的预后,临床中应引起重视。OBJECTIVE To explore the influence of pulmonary infection on C-reactive protein（CRP）,interleukin-2（IL-2）,and tumor necrosis factor（TNF-α）of elderly patients with thoracolumbar compression fractures and analyze the prognosis so as to provide guidance for clinical treatment.METHODS A total of 100 elderly patients with thoracolumbar compression fractures who were treated in the hospital from Jan 2012 to Aug 2015 were recruited as the study objects,then the incidence of pulmonary infection was analyzed,the influence of the pulmonary infection on CRP,IL-2,and TNF-αwas observed,and a one-year follow-up was conducted to analyze the influence of the pulmonary infection on prognosis of fractures.RESULTS Of the 100 elderly patients with thoracolumbar compression fractures,20 had pulmonary infection,with the infection rate 20.0%.The CRP level of the patients with infection was（14.46±2.27）mg/L,significantly higher than（7.04±2.78）mg/L of the patients without infection;the IL-2level of the patients with infection was（3.41±0.80）pg/L,significantly higher than（2.51±0.68）pg/L of the patients without infection;the TNF-αlevel of the patients with infection was（18.48±3.45）pg/ml,significantly higher than（12.51±2.63）pg/ml of the patients without infection（P〈0.05）.The one-year follow-up showed that the healing rate of factures of the patients with infection was 60.0%,significantly lower than 81.3%of the patients without infection（P〈0.05）.CONCLUSIONThe pulmonary infection may lead to the rise of CRP,IL-2,and TNF-αlevels of the elderly patients with thoracolumbar compression fractures and influence the prognosis of the patients,which the hospital should pay high attention to.

关 键 词：胸腰椎压缩性骨折 肺部感染 C-反应蛋白 白细胞介素-2 

分 类 号：R563.1[医药卫生—呼吸系统]