五水头孢唑林钠预防骨科术后切口感染效果及血清炎性因子变化分析  

Effect of cefazolin sodium pentahydrate on prevention of orthopedics department patients with postoperative incision infections and change of serum inflammatory factors

作　　者：卢正波[1] 何兴川[2] 魏毅[1] 田松[1] 雷沛鸿 熊海波[1] 陈春[1] 毛光明[1] 

机构地区：[1]遵义市骨科医院骨一科,贵州遵义563000 [2]遵义医学院附院骨科,贵州遵义563000

出　　处：《中华医院感染学杂志》2016年第17期3987-3989,共3页Chinese Journal of Nosocomiology

基　　金：贵州省优秀科技教育人才省长基金资助项目(209.001.092.06)

摘　　要：目的探讨骨科术后切口感染患者血清炎性因子变化以及五水头孢唑林钠的临床应用效果,为骨科术后切口感染的临床治疗提供参考。方法选取2013年12月-2015年1月医院收治的骨科患者196例,根据患者临床治疗方法的不同分为研究组和对照组,各98例,研究组给予五水头孢唑林钠治疗,对照组给予头孢唑林钠治疗,比较两组患者的感染发生率、治疗疗效率、治疗前后的C-反应蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)等血清炎症因子水平。结果治疗后研究组感染率为4.08%,低于对照组的18.37%;感染患者的CRP、IL-6、IL-8、TNF-α分别为(40.87±5.34)mg/L、(337.24±23.45)pg/ml、(540.83±46.93)pg/ml、(95.83±8.82)pg/ml,高于非感染患者;治疗后,研究组的CRP、IL-6、IL-8、TNF-α分别为(8.34±1.03)mg/L、(175.34±35.03)pg/ml、(335.98±35.03)pg/ml、(41.76±3.03)pg/ml,低于对照组;研究组的总有效率为97.96%,显著高于对照组的86.73%,差异有统计学意义(P<0.05)。结论骨科术后切口感染率较高,患者血清炎性因子会显著升高,给予患者术后五水头孢唑林钠治疗可有效预防术后感染,改善患者炎性因子水平,提高临床综合疗效。OBJECTIVE To explore the change of serum inflammatory factors of orthopedics department patients with postoperative incision infections and observe the clinical therapeutic effect of cefazolin sodium pentahydrate so as to provide guidance for clinical treatment of the postoperative incision infections.METHODS A total of 196 patients who were treated in the orthopedics department from Dec 2013 to Jan 2015 were enrolled in the study and divided into the study group and the control group according to the clinical treatment approach,with 98 cases in each.The study group was treated with cefazolin sodium pentahydrate,while the control group was given cefazolin sodium.The incidence of infections,effective rate of treatment,and the levels of serum inflammatory factors such as C-reactive protein（CRP）,interleukin-6（IL-6）,interleukin-8（IL-8）,and tumor necrosis factorα（TNF-α）before and after the treatment were observed and compared between the two groups of patients.RESULTS The infection rate of the study group was 4.08%after the treatment,lower than 18.37% of the control group.The levels of CRP,IL-6,IL-8,and TNF-αof the patients with infections were respectively（40.87±5.34）mg/L,（337.24±23.45）pg/ml,（540.83±46.93）pg/ml,and（95.83±8.82）pg/ml,higher than those of the patients without infections.The levels of CRP,IL-6,IL-8,and TNF-αof the study group were respectively（8.34±1.03）mg/L,（175.34±35.03）pg/ml,（335.98±35.03）pg/ml,and（41.76±3.03）pg/ml after the treatment,lower than those of the control group.The total effective rate of the study group was 97.96%,significantly higher than86.73%（P〈0.05）.CONCLUSIONThe incidence of postoperative incision infection is high in the orthopedics department,and the levels of serum inflammatory factors of the patients are remarkably elevated.Cefazolin sodium pentahydrate can effectively prevent the postoperative infections,improve the levels of inflammatory factors,and raise the comprehensive clinical efficacy.

关 键 词：骨科 切口感染 炎性因子 五水头孢唑林钠 

分 类 号：R687.3[医药卫生—骨科学]