人乳头瘤病毒多重感染与宫颈病变的相关性研究  

Correlation between multiple infection with human papilloma virus and cervical lesions

作　　者：高燕[1] 张志军[1] 梁文通[1] 姚雪芹[1] 肖雪莲[1] 邹婷[1] 

机构地区：[1]贵州省人民医院妇科,贵州贵阳550002

出　　处：《中华医院感染学杂志》2016年第17期4041-4043,共3页Chinese Journal of Nosocomiology

基　　金：贵州省科技厅基金资助项目(2011-029)

摘　　要：目的探讨人乳头瘤病毒多重感染与宫颈病变的关系,为临床预防宫颈癌提供依据。方法选择2012年8月-2014年8月贵州省人民医院行宫颈液基细胞学检查的3 000例女性,根据2001年国际癌症协会TBS诊断系统,将细胞学异常患者1 088例设为观察组,无异常者1 912例设为对照组;根据阴道镜下病理组织学检查结果,观察组中慢性炎症患者568例,其中宫颈上皮内瘤变(CIN)Ⅰ203例、CINⅡ205例、CINⅢ89例、宫颈鳞状细胞癌患者23例;通过对患者宫颈分泌物进行HPV基因分型检测,分析HPV多重感染在不同级别宫颈病变中的分布。结果 3 000例女性中,HPV感染724例,感染率24.13%;HPV多重感染281例,占9.37%,其中双重感染168例,占59.79%,六重感染仅5例,占1.78%;对照组发生HPV多重感染10例,占0.52%,两组HPV感染率比较差异有统计学意义(P<0.05);观察组中,慢性炎症患者HPV多重感染59例,占10.39%,CINⅠ患者58例,占28.57%,CINⅡ患者88例,占42.93%,CINⅢ患者57例,占64.04%,宫颈鳞状细胞癌患者9例,占39.13%,组间比较差异有统计学意义(P<0.05)。结论多重HPV感染与宫颈病变密切相关,加强对多重HPV感染的控制有利于宫颈癌的防治。OBJECTIVE To explore the relationship between the multiple infections with human papilloma virus（HPV）and the cervical lesions so as to provide guidance for clinical prevention of cervical cancer.METHODS A total of 3 000 women who underwent the liquid-based cervical cytology in Guizhou Province People′s Hospital from Aug 2012 to Aug 2014 were enrolled in the study.According to the 2001 International Cancer Society TBS Diagnostic System,1 088 patients with abnormal cytology were assigned as the observation group,and 1 912 cases without abnormal cytology were set as the control group.Totally 568 patients had chronic inflammation in the observation group,including 203 cases of CINⅠ,205 cases of CINⅡ,89 cases of CINⅢ,and 23 cases of cervical squamous cell carcinoma.The cervical secretions were collected from the patients so as to conduct the HPV genotyping,and the distribution of the multiple infections with HPV in the patients with various grades of cervical lesions was observed.RESULTS Of the 3 000 women,724had HPV infection,with the infection rate 24.13%;totally 281 patients had multiple HPV infection,including 168（59.79%）cases of dual infection and 5（1.78%）cases of sextet infection;10patients had multiple HPV infection in the control group,accounting for 0.52%;there was significant difference in the incidence of HPV infection between the two groups（P〈0.05）.Among the patients with chronic inflammation in the observation group,there were 59（10.39%）cases of multiple HPV infection,58（28.57%）cases of CINⅠ,88（42.93%）cases of CINⅡ,57（64.04%）cases of CINⅢ,and 9（39.13%）cases of cervical squamous cell carcinoma（P〈0.05）.CONCLUSION The multiple HPV infection is closely associated with the cervical lesions.It is an effective way to strengthen the control of the multiple HPV infection so as to prevent the cervical cancer.

关 键 词：人乳头瘤病毒 多重感染 宫颈 癌症 

分 类 号：R373[医药卫生—病原生物学]