低频电刺激对雌激素治疗效果欠佳薄型子宫内膜患者的临床疗效分析  

Clinical efficacy of low-frequency electrical stimulation for patients with thin endometrium with poor response to estrogen therapy

作　　者：宋婧[1] 李环[1] 张巍颖[1] 胡艳[1] 王苏梅[1] 肖爱民[1] 

机构地区：[1]北京大学深圳医院妇产科深圳市女性重大疾病诊断实验室,深圳518035

出　　处：《新医学》2016年第9期618-622,共5页Journal of New Medicine

摘　　要：目的探讨低频电刺激对雌激素治疗效果欠佳薄型子宫内膜患者的临床疗效。方法选择接受雌激素治疗效果欠佳的薄型子宫内膜患者50例,分别继续接受雌激素治疗(对照组,25例)或低频电刺激治疗(治疗组,25例),治疗前、后分别测量尿黄体生成素(LH)峰日子宫内膜厚度,比较2组子宫内膜增长情况,评价疗效。结果治疗后,2组患者的子宫内膜厚度均比治疗前有所增长(P均<0.05),治疗组患者的子宫内膜厚度增长值大于对照组患者(P<0.01)。治疗组中,有效5例,有效率为20%;对照组中无有效病例,有效率为0%,治疗组有效率高于对照组(P<0.05)。对照组患者因治疗后子宫内膜厚度均未达到7 mm,无患者接受冻融胚胎移植(FET),治疗组行FET后胚胎成功种植2例,均为宫内妊娠,其中1例现孕36+周,另1例现孕15+周,产检均未见异常。结论低频电刺激在改善薄型子宫内膜方面明显优于雌激素治疗,可用于治疗雌激素治疗效果欠佳的薄型子宫内膜患者。Objective To evaluate the clinical efficacy of low-frequency electrical stimulation for patients with thin endometrium who exhibited poor response to estrogen therapy. Methods Fifty patients with thin endometrium who had poor response to estrogen therapy were selected. Twenty five patients were continuously administered with estrogen （control group） , and the other 25 received low-frequency electrical stimulation （treatment group）. Endometrium thickness on urinary LH peak day was measured by B ultrasound before and after corresponding treatment. The increase in endometrium thickness was statistically compared between two groups to evaluate the clinical efficacy. Results Following corresponding therapy, the endometrium thickness was significantly increased in both groups （both P 〈0. 05）. The increase in endometrium thickness in the treatment group was significantly higher compared with that in the control group （P = 0. 009 ） . The effective rate in the treatment group was 20% （n =5） , significantly higher than 0% （ n = 0） in the control group （P 〈 0. 05）. In the control group, the endometrium thickness of all patients was less than 7 mm, thus none was eligible for FET. In the treatment group, 2 cases achieved successful embryo implantation after frozen embryo transfer （FET） and both had intrauterine pregnancy. One patient was pregnant for 36 ^＋ weeks and 15^ ＋ weeks for the other case. No abnormality was observed during antenatal examination. Conclusions Low-frequency electrical stimulation is significantly superior to estrogen therapy in treating thin endometrium. Thus, it can be applied to treat thin endometrium for patients who exhibit poor response to estrogen therapy.

关 键 词：薄型子宫内膜 低频电刺激 雌激素 疗效 

分 类 号：R711.74[医药卫生—妇产科学]