血管新生的分子机制与相关疾病  

Angiogenesis:molecular mechanism and related diseases

作　　者：张梦泽[1,2] 李国珅 赵欣童[1,2] 铁璐[1] 

机构地区：[1]北京大学基础医学院药理学系,北京100191 [2]北京大学第三医院,北京100191 [3]北京积水潭医院,北京100035

出　　处：《中国病理生理杂志》2016年第9期1718-1722,1728,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81373405;No.30901803);北京市支持中央高校共建项目--青年英才计划(No.YETP0053);杨森科学研究委员会中国分会研究基金(No.JRCC2011药理01);国家基础科学人才培养基金(No.J1030831/J0108);北京市重点学科基础医学学科建设项目(No.BMU20110254)

摘　　要：血管新生指从已存在的血管上生长出新的毛细血管的过程。该过程十分复杂,依赖血管内皮细胞、成纤维细胞、巨噬细胞和细胞外基质的相互作用,并受促血管新生分子和抗血管新生分子协同调控。生理条件下,促血管新生分子和抗血管新生分子保持动态平衡;一旦平衡被打破,机体就会出现多种疾病,如肿瘤、多种眼科疾病、Angiogenesis is the process of capillary formation from the existing blood vessels,which is regulated by many cytokines. Balance of these cytokines plays an important role in angiogenesis. Unbalance of these cytokines,leading to excessive or insufficient blood vessel,relates to a variety of diseases,such as tumor,ophthalmic diseases and wound healing. Recently,it has been observed that angiogenesis is also involved in Parkinson＇s disease and Alzheimer＇s disease.This review mainly discusses the molecular mechanism of angiogenesis and related diseases,and emphasizes the value of targeting angiogenesis as a strategy to develop drugs for those diseases.

关 键 词：血管新生 血管内皮生长因子 转化生长因子-Β 纤维母细胞生长因子 肿瘤 

分 类 号：R331.3[医药卫生—人体生理学] R363[医药卫生—基础医学]