^(131)I标记卟啉化合物结合光动力治疗对肿瘤生长的抑制作用  

Antiblastic Effect of Porphyrin Labeled with ^(131)I Combined with Photodynamic Therapy to Tumor

作　　者：王关全[1] 郭欣[1] 宋虎[1] 周志军[1] 魏洪源[1] 何佳恒[1] 刘国平[1] 罗顺忠[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,四川绵阳621900

出　　处：《原子能科学技术》2016年第9期1565-1569,共5页Atomic Energy Science and Technology

基　　金：国家科技重大专项资助项目(2014ZX09507007-004);国家科技支撑计划资助项目(2014BAA03B00)

摘　　要：利用放射性核素^(131)I标记了卟啉化合物TPPOH和TPPNH2得到^(131)I-TPPOH和^(131)I-TPPNH_2。建立了接种人肝癌细胞系SMMC-7721的裸鼠皮下肿瘤模型。将^(131)I-TPPOH和^(131)I-TPPNH_2直接注入肿瘤,考察了卟啉化合物、^(131)I和光照对肿瘤生长的抑制效果。结果显示,^(131)I-TPPOH和^(131)I-TPPNH2在注射14d后仍大量滞留在肿瘤组织中。在β射线和光动力的双重作用下,两种^(131)I标记的卟啉化合物均表现出对肿瘤生长较强的抑制能力。以上结果提示,基于"卟啉+^(131)I+光动力治疗"结合的概念可开发一种新的实体肿瘤治疗剂。The porphyrins of TPPOH and TPPNH_2 were labeled with （131）I to obtain 131 ITPPOH and （131）I-TPPNH_2.The human hepatocellular carcinoma cell line SMMC-7721 bearing nude mice was developed.The labeled compounds were injected into tumors directly to investigate the antiblastic effect of porphyrin,131 I and photodynamic therapy（PDT）to tumor.（131）I-TPPOH and （131）I-TPPNH2 still remain in tumors after 14 dpost injection,and it shows that the two porphyrins have good affinity to tumors.By the function ofβ-ray and PDT,the two 131 I labeled porphyrins show a very effective antiblastic effect to tumors.It is possible to develop a novel solid tumor therapy ligand combined＂porphyrin＋（131）I＋PDT＂.

关 键 词：卟啉 131I 光动力治疗 肿瘤 

分 类 号：TL817.2[核科学技术—核技术及应用]