血小板与冷沉淀联合输注在大出血临床治疗中应用的Meta分析  

Therapeutic Effects of Co-infusion of Platelets and Cryoprecipitation in the Treatment of Patients with Massive Blood Loss:A Meta-analysis

作　　者：林姝婷[1] 赖冬[1] 龙敏[1] 

机构地区：[1]厦门市第二医院,福建厦门361021

出　　处：《中外医学研究》2016年第26期1-4,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：2014年厦门市科技计划项目(项目编号:3502Z20149021)

摘　　要：目的:系统评价患者血小板与冷沉淀联合输注在大出血临床治疗中的效果。方法:计算机检索中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)和万方数据库(Wanfang Date)。采用Rev Man 5.3软件对15篇随机对照试验(RCTs)的1316例患者进行Meta分析。结果:与单用血小板相比,血小板与冷沉淀联合输注组的PT、APTT和平均止血时间均显著短(P<0.01),24 h内悬浮红细胞使用量显著少(P<0.01);止血有效率显著高(P<0.01),输血后的PLT无显著变化(P>0.05);与单用冷沉淀相比,血小板与冷沉淀联合输注组的PT、APTT和平均止血时间均显著短(P<0.01),24 h内悬浮红细胞使用量显著少(P<0.01),输血后的PLT和止血有效率显著高(P<0.01)。结论:血小板与冷沉淀联合输注有效纠正了大出血患者的凝血功能障碍,止血效果更为显著,为挽救患者的生命赢得了宝贵的时间。Objective： To systematically evaluate therapeutic effects of co-infusion of platelets and cryoprecipitation in the treatment of patients with massive blood loss.Method： The domestic lectures were retrieved from databases including CBM, CNKI, Wanfang Database.The meta-analyses were performed with RevMan 5.3 software for 15 randomized controlled trials（RCTs） of 1316 patients.Result： Compared with platelet group, PT, APTT and the average hemostasis time of co-infusion were all significantly shorten（P〈0.01）, the consumption of suspended red blood cells in 24 h was decreased significantly（P〈0.01）, and hemostatic efficiency was improved significantly（P〈0.01）, and post transfusion PLT had no significant changes（P〉0.05）.Compared with cryoprecipitation group, PT, APTT and the average hemostasis time of co-infusion were all significantly shorten（P〈0.01）, the consumption of suspended red blood cells in 24 h was decreased significantly（P〈0.01）, and hemostatic efficiency and post transfusion PLT were improved significantly（P〈0.01）.Conclusion： Co-infusion overcome the coagulation disorders in patients with massive blood loss, and it is the best method of hemostatic effect.It will win enough time for saving the patient＇s precious life.

关 键 词：血小板 冷沉淀 联合输注 大出血 META分析 

分 类 号：R457.1[医药卫生—治疗学]