人参皂苷Rb1抗骨质疏松作用机制的研究进展  

Research advance for mechanism of ginsenoside Rb1 on osteoporosis

作　　者：贝家欣 夏海珊[1] 卢家淇 许碧莲[1] 崔燎[1,2] 吴铁[1,3] 邹丽宜[1,3] 

机构地区：[1]广东医科大学药学院药理学教研室 [2]广东天然药物研究与开发重点实验室 [3]广东医科大学广东润和生物科技有限公司辅酶Q10联合研究中心

出　　处：《中国临床药理学与治疗学》2016年第8期950-955,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金资助项目(81373499);广医润和辅酶Q10联合研究中心资助课题(2XX14002)

摘　　要：人参皂苷Rb1(ginsenoside Rb1)是中药人参中活性较强的二醇类化合物。有研究表明,人参皂苷Rb1对心血管系统、内分泌系统、免疫系统、中枢神经系统等疾病具有较好的疗效。而在防治骨质疏松方面,目前已有报道主要是通过上调RUNX2蛋白的表达、调节Wnt/β-catenin信号通路、护骨素(OPG)、核因子κB受体活化因子配体(RANKL)和抑制基因p21和p27的mRNA的表达来促进成骨分化,以及通过抑制RANKL诱导的TNF-α的表达、NF-κB活性、破骨细胞特异性转录因子(c-Fo、NEATc1)活性、MAPKS通路来抑制骨吸收,从而达到防治骨质疏松的疗效。本文将对人参皂苷Rb1防治骨质疏松的作用机制研究进展作一综述,以期为更深入探讨其对抗骨质疏松作用的研究提供参考。Ginsenoside Rb1 is a kind of active glycol compounds of traditional Chinese medicine Panax ginseng. There is some evidence showing that ginsenoside Rb1 has curative effect on numerous diseases of cardiovascular system,endocrine system,immune system,central nervous system,et al. As for treating osteoporosis,the mechanisms of ginsenoside Rb1 on osteoporosis are complicated according to the results of related experiments and literature reviews. The proliferation and differentiation of osteoblasts by Ginsenoside Rb1 were increased through up-regulating expression of RUNX2, modulating Wnt / β-catenin signal pathway,OPG,RANKL and inhibiting the gene expression of p21 and p27. Osteoclast was also inhibited by restraining RANKL-induced TNF-α,NF-κB,c-Fo,NEATc1 mRNA expression and modulating MAPKS signal pathway. To review the mechanisms of ginsenoside Rb1 on osteoporosis does good to more further and deeper researches on it.

关 键 词：人参皂苷RB1 骨质疏松 成骨分化 骨吸收 

分 类 号：R966[医药卫生—药理学]