轮状病毒感染及肠外扩散机制的研究进展  

Research advances on mechanism of rotavirus infection and extra-intestinal spread

作　　者：齐敏[1] 董淮富[1] 

机构地区：[1]蚌埠医学院第一附属医院儿科

出　　处：《中国临床药理学与治疗学》2016年第8期956-960,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：轮状病毒(RV)是引起婴幼儿腹泻的主要病原体,它不仅局限于胃肠道,也可引起肠外感染。现有研究显示,儿童和动物感染RV后,病毒可以从肠内播散到血液,并可能广泛播散,从而引起非肠道疾病。RV可能通过受体介导的内吞途径或者直接入侵的方式感染宿主细胞,突破肠道屏障,经过血液循环和淋巴途径,在免疫机制的参与下,播散至肠外器官和组织而致病。本文将近年来RV感染及肠外扩散的相关机制方面的研究进展作一综述。Rotavirus is the main cause of diarrhea in infants and young children. It not only infects the gastrointestinal tract,but also can cause extra-intestinal infection. Research shows that the virus can spread from the intestines to blood and further results in non-intestinal disease when children and animals are infected with RV. RV may infect host cells through the pathway of receptor-mediated endocytosis or direct membrane penetration; break through the intestinal barrier,spread to the intestinalorgans or tissues and cause disease through blood circulation, lymphatic pathway and the immune mechanisms. This paper reviews recent researches on rotavirus infection and the mechanism of extra-intestinal infection.

关 键 词：轮状病毒感染 机制 肠外扩散 抗原血症 

分 类 号：R723[医药卫生—儿科]