PCI术后再狭窄患者血清IL-6、IL-10、CRP水平变化及意义  

Significance of IL-6, IL-10 and CRP on Restenosisat Patients after PCI

作　　者：王琦[1] 王康鸣 

机构地区：[1]海南省海口市人民医院暨中南大学湘雅医学院附属海口医院老年病科,海南海口570208

出　　处：《医学临床研究》2016年第8期1565-1567,共3页Journal of Clinical Research

摘　　要：[目的]分析经皮冠脉介入术（PCI）术后再狭窄患者手术前后不同时间的白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、C反应蛋白（CRP）水平变化，探讨其临床意义。[方法]回顾性分析本院心内科收治的行PCI治疗的130例CHD患者的临床资料，根据患者术后半年再次行冠状动脉造影检查是否发生再狭窄，将其分为再狭窄组（n=34）和无狭窄组（n=96），比较两组患者术前、术后6h、48h、7d的IL-6、IL-10、CRP水平差异。[结果]再狭窄组和无狭窄组患者术前、术后冠脉最小管腔径差异无统计学意义（P〉0．05），再狭窄组患者的X线曝光时间、造影剂用量、手术时间均显著的高于无狭窄组患者（P〈0．05）；再狭窄组患者术后6h、48h的IL-6、CRP水平较无狭窄组显著的提高（P〈0．05）；再狭窄组患者术后6h、48h的IL-10水平较无狭窄组显著的降低（P〈0．05）。[结论1PCI手术前后IL-6、IL-10及CRP等炎症指标水平变化可反应患者手术后的炎症程度，可能与患者术后发生再狭窄具有-定的关系。[Objective] To analyze the changes of interleukin - 6 （IL-6）, interleukin -10 （IL-10）, C reac- tive protein （CRP） of restenosisat patients before and after operation and to explore its clinical significance. [Methods] Retrospective analysis of the clinical data of 130 patients with CHD who were treated with percuta- neous coronary intervention （PCI） in the Department of Cardiology of our hospital was conducted. Half a year after operation, patients were again performed coronary angiography to check the occurrence of restenosis, and they were accordingly divided into restenosis group （ n = 34） and non stenosis group （ n = 96）. Level differ- ence of IL-6. IL-10 and CRP of the two groups of patients were compared before and after operation. [Results] There was no significant difference in the minimum lumen diameter of the coronary artery between the resteno- sis group and the non stenosis group （ P ）0.05） ; The X-ray exposure time, dose of contrast medium and＇op- eration time of the restenosis group were significantly higher than those of the non stenosis group （ P〈0.05） Compared with the non stenosis group, the CRP and IL-6 levels of 6 h and 48 h after operation were signifi- cantly increased in patients with the restenosis （ P〈0.05） ] The IL-10 level of 6h and 48h post operation of the restenosis group was significantly lower than that in the non stenosis group （ P〈0.05）.[Conclusion]Before and after PCI surgery, the changes of IL-6, IL-10 and CRP and other indicators of inflammation may reflect the degree of postoperative inflammation of patients, and they may be related to the occurrence of rest- enosis after operation.

关 键 词：血管成形术 经腔 经皮冠状动脉 冠状动脉再狭窄 白细胞介素6 白细胞介素10 C反应蛋白质 

分 类 号：R654.2[医药卫生—外科学]